国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (5): 524-527.

• 综述 • 上一篇    下一篇

SDF-1/CXCR4与妊娠期高血压疾病关系的研究进展

朱小华，罗新   

  1. 510630 广州，暨南大学附属第一医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-10-15 发布日期:2015-10-15

Progress of SDF-1/CXCR4 and Hypertensive Disorder Complicating Pregnancy

ZHU Xiao-hua，LUO Xin   

  1. Department of Obstetrics and Gynecology，The First Affiliated Hospital of Jinan University，Guangzhou 510630，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-10-15 Online:2015-10-15

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摘要： 基质细胞衍生因子1（SDF-1）是CXC族趋化因子受体4（CXCR4）的唯一生理学配体，CXCR4可与SDF-1特异性结合形成SDF-1/CXCR4生物轴，从而完成相应的生物学效应。SDF-1与其受体CXCR4在机体的生理和病理过程中发挥着重要的作用。SDF-1/CXCR4在机体的免疫炎症、胚胎发育、激活抗调亡途径、造血干细胞迁移、归巢、调控血管生成及妊娠期高血压疾病（HDCP）、子痫前期等多种生物学过程中的作用受到关注，已成为当今生物学研究的热点之一。在正常的妊娠过程中，胎盘形成起到了决定性的作用，因此探讨胎盘床中SDF-1/CXCR4的表达为研究HDCP的发病机制提供了可能的探索途径。在绒毛膜外滋养层细胞的侵袭和子宫螺旋动脉重铸的过程中，不良的血管形成和细胞抗凋亡能力的异常是导致HDCP发病的关键病因。研究表明妊娠晚期发生子痫前期孕妇胎盘床中SDF-1/CXCR4表达含量的下降与HDCP的发病存在相关性。就SDF-1及CXCR4在HDCP中的研究进展进行综述。

关键词: 基质细胞衍生因子1, 趋化因子, CXC, 高血压, 妊娠性, 先兆子痫

Abstract: Stromal cell derived factor 1 （SDF-1） is only physiological ligand of CXC chemokine receptor 4 （CXCR4）. CXCR4 can specifically bind to SDF-1 formed a SDF-1/CXCR4 biological axis, thus completing the corresponding biological effects. SDF-1 and its receptor CXCR4 plays an important role in physiological and pathological processes in the body. A large number of studies show that the roles of SDF-1/CXCR4 in immunity and inflammation, embryo development, activation of anti-apoptotic pathways, hematopoietic stem cell migration, homing, regulation of angiogenesis, hypertensive disorder complicating pregnancy （HDCP）, preeclampsia and other biological processes have become a hot spot in biological research. In normal pregnancy, the formed of placenta played a decisive role, so the study on the expression of SDF-1/CXCR4 in the placental bed HDCP will provide a way to explore the possible pathogenesis of HDCP. Bad blood vessel formation process of erosion in trophoblast cells and bad remodeling of the spiral arteries in cell and irregular anti-apoptosis ability exceptions are the key causes of HDCP. Research shows that the decreased of SDF-1/CXCR4 in pregnant women with preeclampsia′s placenta bed has a significant incidence of hypertensive disorder complicating pregnancy. This article reviews SDF-1 and CXCR4′s research progress in hypertensive disorders in pregnancy.

Key words: Stromal cell-derived factor 1, Chemokines, CXC, Hypertension, pregnancy-induced, Pre-eclampsia