国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (4): 390-394.

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microRNA调控上皮-间质转化影响卵巢癌侵袭转移的研究进展

张越，张殊   

  1. 200127 上海交通大学医学院附属仁济医院妇产科，上海市妇科肿瘤重点实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-08-15 发布日期:2014-08-15
  • 通讯作者: 张殊

Relationship between miRNA Regulating Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer

ZHANG Yue，ZHANG Shu   

  1. Department of Obstetrics and Gynecology，Renji Hospital，School of Medicine，Shanghai Jiao Tong University；Shanghai key Laboratory of Gynecologic Oncology， Shanghai 200127，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-08-15 Online:2014-08-15
  • Contact: ZHANG Shu

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被引次数

5

摘要： 卵巢癌是女性生殖系统三大恶性肿瘤之一，死亡率居妇科肿瘤之首，卵巢癌的转移是造成患者死亡的重要原因。上皮-间质转化（epithelial-mesenchymal transition，EMT）是上皮细胞表型向间质细胞表型转变的过程，与肿瘤侵袭、转移及耐药等恶性行为密切相关。MicroRNA（miRNA）是一类内源性非编码的小分子RNA，能在转录后水平调控编码基因表达，其能调控EMT的过程受到越来越多关注。多种miRNA在卵巢癌中表达存在差异，并参与卵巢癌的发生、发展过程，提示miRNA可能用于卵巢癌早期诊断、治疗、预后评估。现就近年对卵巢癌中miRNA调控EMT机制及其与卵巢癌侵袭转移关系的研究进行综述。

关键词: 卵巢肿瘤, 癌, 上皮-间质转化, 微RNAs, 肿瘤干细胞, 肿瘤转移

Abstract: Ovarian cancer is a common gynecological malignancy and one of leading causes of cancer-related morbidity and mortality in female patients around the globe. The metastasis of ovarian cancer is an important factor in causing deaths. EMT （epithelial-mesenchymal transition） refers to the transition process from the phenotype of epithelial cells to mesenchymal phenotype and is closely associated with the malignant progression of tumors in its invasion and metastasis. MicroRNA （miRNA） are a class of small molecule and noncoding RNAs which inhibit translation of the mRNA transcript of the genes expression，and become more and more concerned in regulating EMT progress. Many kinds of miRNA expressed abnormally and related to the occurrence and development of ovarian cancer，are expected to be used in early diagnosis，treatment and prognosis.In this review，we presented recent research regarding the role of EMT and related microRNAs in the malignant progression of ovarian cancer.

Key words: Ovarian neoplasms, Carcinoma, Epithelial-mesenchymal transition, MicroRNAs, Neoplastic stem cells, Neoplasm metastasis