国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (4): 473-476.

• 综述 • 上一篇    下一篇

瘦素及瘦素受体与子宫内膜异位症关系的研究进展

张唯一，李亚里   

  1. 100853 中国人民解放军总医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-08-15 发布日期:2014-08-15
  • 通讯作者: 李亚里

Association of Leptin and OB-R Research Progress in Endometriosis

ZHANG Wei-yi，LI Ya-li   

  1. Department of Obstetrics and Gynecology，Chinese PLA General Hospital，Beijing 100853，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-08-15 Online:2014-08-15
  • Contact: LI Ya-li

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摘要： 子宫内膜异位症（EMs）是一种具有恶性肿瘤生物学行为的妇科良性疾病，以痛经、盆腔包块及不孕为特征，其发病率呈上升趋势，严重影响患者的生活质量，但其发病机制目前尚不清楚。近年大量基础和临床研究发现，瘦素及其受体的表达及调控在EMs发生、发展过程中起重要作用，其参与血管新生、细胞增殖与凋亡、免疫调节、炎症反应以及新陈代谢。研究EMs病程中瘦素和瘦素受体及其上、下游因子的表达及变化规律，可为EMs发病机制的研究、临床治疗和新药的开发应用提供新的切入点。

关键词: 瘦素, 受体, 瘦素, 子宫内膜异位症, 孕激素类, 雌激素类

Abstract: Endometriosis is a gynecologic benign disease with biological behavior of malignant tumor， characterized by the feature of pain，infertility and pelvic mass. The incidence of the disease rises up recently which affected the life quality seriously，but the pathogenic mechanism is unclear. A number of basic and clinical research discovered that the expression and regulation of leptin and OB-R played an important role in the occurrence and progress of endometriosis including vascular neogenesis，cell proliferation and apoptosis，immunological regulation，inflammation reaction and metabolism. It can provide the new breakthrough point of endometriosis pathogenic study，clinical treatment and new drug exploitation by researching on the leptin，OB-R，regularity of the expression and change of its upstream and downstream gene.

Key words: Leptin, Receptors, leptin, Endometriosis, Progestins, Estrogens