国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (4): 477-480.

• 综述 • 上一篇    

血管内皮生长因子及相关因子与含铜宫内节育器致子宫异常出血的关系

赵璐，殷震惠，杨华   

  1. 300100 天津市中心妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-08-15 发布日期:2014-08-15
  • 通讯作者: 赵璐

Relationship between VEGF and Related Factors and Abnormal Uterine Bleeding Induced by Intrauterine Device

ZHAO Lu，YIN Zhen-hui，YANG Hua   

  1. Tianjin Central Hospital of Gynecology Obstetrics，Tianjin 300100，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-08-15 Online:2014-08-15
  • Contact: ZHAO Lu

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摘要： 宫内节育器（intrauterine device，IUD）是目前广泛使用的长效避孕方法之一。目前中国已普遍使用含铜IUD，但是放置含铜IUD的妇女常出现一些不良反应，如月经过多、不规则出血、白带异常和疼痛等，其中以子宫异常出血发生率最高，严重影响了患者对含铜IUD的认可和接受性，这也是一直困扰临床的一个不可忽视的问题。目前已证明人子宫内膜存在多种血管生成因子。其中血管内皮生长因子（VEGF）是子宫内膜血管形成的重要调控因子，并受多种因子调控。对VEGF及相关因子与含铜IUD致子宫异常出血关系的多项研究，为含铜IUD不良反应的靶向治疗开辟了新的前景。

关键词: 宫内避孕器, 子宫出血, 血管内皮生长因子类, 血管生成素类

Abstract: Intrauterine device（IUD） is one of the widely used long-acting contraceptive methods. At present，our country has the widespread use of copper containing IUD，but the placement of IUD women often have some adverse reactions，such as menorrhagia，irregular bleeding，abnormal vaginal discharge，pain，especially with the highest incidence of abnormal uterine bleeding. Patients with a serious impact on recognition of copper containing IUD and acceptance，which has been plagued by a problem that can not be ignored in clinic. At present it has been proved that human endometrium contains a variety of angiogenesis factor. Vascular endothelial growth factor（VEGF） is an important regulator of endometrial vessels formed，and affected by many factors. A number of research on the relationship between VEGF and related factors and the copper IUD induced abnormal uterine bleeding，the copper containing IUD side reactions of targeted therapy has opened up a new prospect.

Key words: Intrauterine devices, Uterine hemorrhage, Vascular endothelial growth factors, Angiopoietins