内皮细胞特异性分子与子痫前期关系的研究进展

doi:10.12280/gjfckx.20200798

摘要/Abstract

摘要：

子痫前期是一种妊娠期特有疾病,血管内皮细胞受损是目前普遍认可的主要病理生理变化之一。内皮细胞特异性分子（endocan）作为内皮功能障碍的一种新型生物标志物,在其多种生物学功能中,作为一种血管保护分子可以保护内皮免受炎症细胞的迁移和增殖等,所以在心血管系统疾病、肿瘤、脓毒症等方面被广泛研究,成为诊断及治疗疾病的有效靶点。近年研究发现endocan在子痫前期患者血清及胎盘中均存在差异性表达,提示endocan可能参与子痫前期的发病。因此,深入研究endocan与子痫前期的相关性,有利于揭示子痫前期的发病机制,为该病的早期预防与治疗提供依据。就endocan与子痫前期的关系研究进展进行综述。

关键词: 先兆子痫, 内皮细胞特异性分子, 血管内皮生长因子类, 内皮功能障碍

Abstract:

Pre-eclampsia is a unique disease during pregnancy, and its pathogenesis is the research focus of many scholars. Vascular endothelial cell dysfunction is one of the main pathophysiological changes generally recognized. As a new type of biomarker for endothelial dysfunction, endothelial cell-specific molecule (endocan) can protect endothelium from the migration and proliferation of inflammatory cells. Vascular system diseases, tumors, sepsis, etc. have been extensively studied and become effective targets for diagnosis and treatment of diseases. Recent studies have found that endocan is differentially expressed in the serum and placenta of patients with pre-eclampsia, suggesting that endocan may be involved in the pathogenesis of pre-eclampsia. Therefore, in-depth study of the relationship between endocan and pre-eclampsia will help reveal the pathogenesis of pre-eclampsia and provide a basis for early prevention and treatment of the disease. This article reviews the research progress of the relationship between endocan and pre-eclampsia.

Key words: Pre-eclampsia, Endocan, Vasular endothelial growth factors, Endothelial dysfuction

隋欣爽, 孙敬霞, 袁晶, 曹珊, 戴晨光. 内皮细胞特异性分子与子痫前期关系的研究进展[J]. 国际妇产科学杂志, 2021, 48(2): 169-173.

SUI Xin-shuang, SUN Jing-xia, YUAN Jing, CAO Shan, DAI Chen-guang. Research Progress on the Relationship between Endocan and Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2021, 48(2): 169-173.

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