国际妇产科学杂志

国际妇产科学杂志 ›› 2017, Vol. 44 ›› Issue (1): 23-26.

• 综述 • 上一篇    下一篇

外泌体在卵巢癌发病及诊疗中的研究进展

张涛1,汪希鹏2   

  1. 1. 上海市第一妇婴保健院
    2. 同济大学附属第一妇婴保健院妇科
  • 收稿日期:2016-06-16 修回日期:2016-10-13 出版日期:2017-02-15 发布日期:2017-03-28
  • 通讯作者: 汪希鹏 E-mail:xipengwang@hotmail.com
  • 基金资助:
    国家自然科学基金

Progress of Exosome in the Pathogenesis, Diagnosis and Treatment of Ovarian Cancer

Zhang Tao1,   

  • Received:2016-06-16 Revised:2016-10-13 Published:2017-02-15 Online:2017-03-28
  • Supported by:
    National Natural Science Foundation

PDF (PC)

7209

摘要： 【摘 要】卵巢癌是妇科肿瘤中死亡率最高的恶性肿瘤，由于缺乏特异性标志物，早期诊断存在很大困难。外泌体是近年来多种领域的研究热点，其分布广泛，内容丰富，功能多变，越来越多的进入肿瘤研究领域。外泌体可来源于多种细胞和体液，通过运载多种蛋白、脂质、mRNA及miRNA片段等生物学功能物质，介导细胞-细胞间信息交流，促进肿瘤的发生发展。此外，由于肿瘤相关外泌体可表达特异性抗原，这为肿瘤的诊断与治疗提供了新思路。现就外泌体在卵巢癌发生发展、诊断和治疗中的研究做一综述，以期更确切、更全面揭示外泌体在卵巢癌中的作用机制，为新的治疗方法提供理论基础。

关键词: 外泌体, 卵巢癌, 靶向治疗, 药物传送系统

Abstract: 【Abstract 】Ovarian cancer is the highest mortality rate of malignant tumor in gynecologic cancer. Due to the lack of specific markers, the early diagnosis of ovarian cancer is very difficult. In recent years, The exosome has become a hot research topic in many fields，as for it’s widely distributed，rich content and functional diversity，is more and more into the field of cancer research. Exosomes can be derived from many kinds of cells and body fluid. They can mediate cell - cell information exchange, promote the occurrence and development of tumors through the delivery of a variety of proteins, lipids, mRNA and miRNA fragments and other biological functions. In addition, due to the specific antigen of tumor related, exosomes provide a new idea for the diagnosis and treatment of tumors. This article reviews research on the diagnosis and treatment of exosomes in the development and occurrence of ovarian cancer, the mechanism is more precise and more comprehensive in order to reveal the exosomes in ovarian cancer, and provide a theoretical basis for the new treatment methods.

Key words: Exosome, Ovarian cancer, Targeted therapy, Drug delivery system.