国际妇产科学杂志

国际妇产科学杂志 ›› 2019, Vol. 46 ›› Issue (1): 39-43.

• 综述 • 上一篇    下一篇

母胎免疫中巨噬细胞作用机制的研究进展

黄金花，梁梦晨，姜梦琦，刘悦，丁之德   

  1. 200025 上海交通大学医学院临床医学系2016级临床八年制（黄金花，梁梦晨，姜梦琦），组织胚胎学与遗传发育学系（刘悦，丁之德）
  • 收稿日期:2018-09-25 修回日期:2018-11-25 出版日期:2019-02-15 发布日期:2019-02-15
  • 通讯作者: 刘悦，E-mail：liuyue@shsmu.edu.cn；丁之德，E-mail：zding@ shsmu.edu.cn E-mail:zding@shsmu.edu.cn
  • 基金资助:
    上海交通大学第十二期大学生创新项目（1218006），上海交通大学基础医学院RBL项目（2018002）

The Research Advances in the Mechanism of Macrophage Effects on Maternal-Fetal Immune

HUANG Jin-hua，LIANG Meng-chen，JIANG Meng-qi，LIU Yue，DING Zhi-de   

  1. Department of Clinical Medicine，Grade 2016（HUANG Jin-hua，LIANG Meng-chen，JIANG Meng-qi），Department of Histology，Embryology，Genetics and Developmental Biology（LIU Yue，DING Zhi-de），School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:2018-09-25 Revised:2018-11-25 Published:2019-02-15 Online:2019-02-15
  • Contact: LIU Yue，E-mail：liuyue@shsmu.edu.cn；DING Zhi-de，E-mail：zding@shsmu.edu.cn E-mail:zding@shsmu.edu.cn

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摘要： 胚泡植入是妊娠过程中的关键步骤，包括胚泡在子宫内膜的定位、黏附和侵入。对于母体子宫来说，胚泡是一种半同种异型移植物，植入成功与否依赖于母体子宫免疫细胞对胚泡的识别，以及随后对其建立和维持的免疫耐受。巨噬细胞是母胎交流中的第二大类免疫细胞，在母胎界面免疫耐受的建立、维持，组织重建以及螺旋动脉重塑过程中发挥关键作用。近年来，许多研究发现巨噬细胞分化和功能异常与病理性妊娠有关，而研究蜕膜巨噬细胞的种类和功能对妊娠异常性疾病的诊断与治疗均有重要的意义。综述母胎界面中巨噬细胞的来源、分类及其在胚泡植入和病理性妊娠过程中作用。

关键词: 巨噬细胞, 胚胎植入, 妊娠并发症, 母胎界面, 免疫调节

Abstract: Blastocyst implantation is a critical stage in the pregnancy process, including apposition, adhesion and invasion of blastocysts in the endometrium. The blastocyst is a semi-allogeneic transplant for the uterus. The successful implantation dependents on the immune tolerance established and maintained by maternal immune cells located in the uterus. As the second largest immune cell group at the maternal-fetal interface, macrophages play a critical role in establishing and maintaining maternal-fetal immune tolerance and remodeling tissue and spiral arteries. Recent studies have found that abnormal differentiation or dysfunction of macrophages is significantly correlated with pathological pregnancy. Thus, studies on the types and functions of decidual macrophages will help us to improve the diagnosis and treatment of pathologic pregnancy. This review is mainly focused on research progresses in the derivation and classification of macrophages at the maternal-fetal interface as well as the roles of the macrophages in blastocyst implantation and pathological pregnancy.

Key words: Macrophages, Embryo implantation, Pregnancy complications, Maternal-fetus interface, Immune regulation