关键词: 妇产科, 医院, 妇科外科手术, 手术期间, 脓毒症, 毒血症, 革兰氏阴性菌, 炎症

Abstract: Objective：To analyze the characteristics of perioperative sepsis in obstetrics and gynecology, and to provide evidence for the prevention and treatment of sepsis. Methods: The cases of sepsis diagnosed in Beijing Obstetrics and Gynecology Hospital from January 2011 to December 2017 were collected. The characteristics of the cases were analyzed. According to the pathogens, the differences between the G- bacteria group and the G+ cocci group were compared. Results: The pathogens of perioperative sepsis in gynecology and obstetrics were mostly G- bacteria, accounting for 71.4%. The white blood cell count, C-reactive protein level and procalcitonin level were significantly increased in patients with sepsis. The fibrinogen (FIB) of the G- bacteria group was significantly lower than that of the G+ cocci group (P=0.045). The international normalized ratio (INR) of the G-bacteria group (P=0.043) and the D-dimer (DD) (P=0.039) was significantly higher than the G+ cocci group. The differences were statistically significant. 5 patients with septic shock were all G- bacteria infection. Conclusions: Perioperative sepsis in obstetrics and gynecology is mainly caused by G- bacteria infection.This type of sepsis has a strong inflammatory response, severe coagulopathy, and septic shock tendency. Early detection, empirical anti-infective therapy, and early application of low molecular weight heparin to prevent disseminated intravascular coagulation (DIC) are critical for improving prognosis.

Key words: Obstetrics and gynecology department, hospital, Gynecologic surgical procedures, Intraoperative period, Sepsis, Toxemia, Gram-negative bacteria, Inflammation