国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (6): 436-439.

• 综述 • 上一篇    下一篇

子宫内膜癌化疗进展

沈晓燕， 向 阳   

  1. 100730 北京，中国医学科学院　北京协和医学院　北京协和医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-12-15 发布日期:2010-12-15

Research Progress on Chemotherapy of Endometrial Carcinoma

SHEN Xiao-yan，XIANG Yang   

  1. Department of Obstetrics and Gynecology，Peking Union Medical College Hospital，Peking Union Medical College，Chinese Academy of Medical Sciences，Beijing 100730，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-12-15 Online:2010-12-15

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摘要： 化疗是晚期或复发性子宫内膜癌的主要治疗方式。化疗在高危子宫内膜癌中的作用已引起重视。临床研究GOG209将卡铂/紫杉醇（carboplatin and paclitaxel，TcP）与子宫内膜癌标准化疗方案阿霉素/紫杉醇/顺铂联合化疗（doxorubicin，paclitaxel and cisplatin，TAP）进行比较，其结果值得期待。放疗联合化疗可以改善高危早期患者的生存。续贯化疗-放疗-化疗模式（chemotherapy，interval radiation and further chemotherapy，CRC）有利于改善晚期子宫内膜癌患者的生存。需重视化疗的毒副作用， 序贯双联疗法（卡铂/紫杉醇和卡铂/阿霉素）是一种降低药物毒性的策略。

关键词: 子宫内膜肿瘤, 抗肿瘤联合化疗方案, 临床对照试验, 治疗, 药物疗法

Abstract: Chemotherapy are the main treatment for advanced or recurrent endometrial cancer. The role of chemotherapy in the high-risk patient is currently the focus of the researchers. Among the current Gynaecologic Oncology Group（GOG） trials in endometrial cancer treatment，GOG209 comparing carboplatin and paclitaxel （TcP） with the triplet of doxorubicin，paclitaxel and cisplatin（TAP） is the most anticipated study and may be challenge the current standard regimen of TAP. Radiation plus chemotherapy significantly improved overall survival（OS） and progression-free survival（PFS） for patients with early endometrial cancer at high risk for micrometastases. Chemotherapy， interval radiation and further chemotherapy（CRC） may be the most favorable sequence given in the improved overall survival in patients with endometrial cancer. The toxicity of cytotoxic agents should not be ignored. The sequential doublet therapy with carboplatin/paclitaxel and carboplatin/doxorubicin are strategies that may be considered to reduce drug toxicity.

Key words: Endometrial neoplasms, Antineoplastic combined chemotherapy protocols, Controlled clinical trial, Therapy, Drug therapy