国际妇产科学杂志 ›› 2021, Vol. 48 ›› Issue (2): 224-229.doi: 10.12280/gjfckx.20200820
收稿日期:
2020-09-04
出版日期:
2021-04-15
发布日期:
2021-04-16
通讯作者:
臧春逸
E-mail:zangcy@ccmu.edu.cn
基金资助:
XU Qian, WANG Yi-yi, ZANG Chun-yi△()
Received:
2020-09-04
Published:
2021-04-15
Online:
2021-04-16
Contact:
ZANG Chun-yi
E-mail:zangcy@ccmu.edu.cn
摘要:
宫腔粘连是各种致病因素作用下的子宫内膜损伤性疾病,严重影响女性的生殖健康和生育功能。妊娠期宫腔操作是导致宫腔粘连的主要病因,宫腔感染、子宫内膜血流低灌注等也可能与该病发生密切相关。宫腔镜检查是诊断宫腔粘连的金标准,宫腔镜宫腔粘连分离术是治疗该病的首选方法,术后多需联用辅助治疗措施预防再粘连发生,但目前尚未对该病的最佳诊疗方案达成统一的评价标准。就宫腔粘连形成的临床病因及诊疗相关研究进行综述,旨在预防宫腔粘连,为早发现、早诊断并及时采取措施提供依据,避免对子宫内膜造成更严重的伤害,为宫腔粘连的治疗开辟新思路。
许阡, 王祎祎, 臧春逸. 宫腔粘连临床病因学及诊疗研究进展[J]. 国际妇产科学杂志, 2021, 48(2): 224-229.
XU Qian, WANG Yi-yi, ZANG Chun-yi. Advances in the Clinical Etiology, Diagnosis and Therapy of Intrauterine Adhesions[J]. Journal of International Obstetrics and Gynecology, 2021, 48(2): 224-229.
[1] | 中华医学会妇产科学分会. 宫腔粘连临床诊疗中国专家共识[J]. 中华妇产科杂志, 2015,50(12):881-887. doi: 10.3760/cma.j.issn.0529-567x.2015.12.001. |
[2] | Fritsh H. Ein Fall von volligem Schwund der Gebarmutterhohle nach Auskratzung[J]. Zentralbl Gynaekol, 1894,18(2):1337-1342. |
[3] |
Asherman JG. Amenorrhoea traumatica (atretica)[J]. J Obstet Gynaecol Br Emp, 1948,55(1):23-30. doi: 10.1111/j.1471-0528.1948.tb07045.x.
doi: 10.1111/j.1471-0528.1948.tb07045.x pmid: 18902559 |
[4] |
Puente Gonzalo E, Alonso Pacheco L, Vega Jiménez A, et al. Intrauterine infusion of platelet-rich plasma for severe Asherman syndrome: a cutting-edge approach[J]. Updates Surg, 2020 Jun 8. doi: 10.1007/s13304-020-00828-0.Epub ahead of print.
doi: 10.1007/s13304-021-01040-4 pmid: 33783765 |
[5] |
Santamaria X, Isaacson K, Simón C. Asherman′s Syndrome: it may not be all our fault[J]. Hum Reprod, 2018,33(8):1374-1380. doi: 10.1093/humrep/dey232.
doi: 10.1093/humrep/dey232 pmid: 31986212 |
[6] |
Xiao S, Wan Y, Xue M, et al. Etiology, treatment, and reproductive prognosis of women with moderate-to-severe intrauterine adhesions[J]. Int J Gynaecol Obstet, 2014,125(2):121-124. doi: 10.1016/j.ijgo.2013.10.026.
doi: 10.1016/j.ijgo.2013.10.026 pmid: 24598346 |
[7] |
Can S, Kirpinar G, Dural O, et al. Efficacy of a New Crosslinked Hyaluronan Gel in the Prevention of Intrauterine Adhesions[J]. JSLS, 2018,22(4):e2018.00036. doi: 10.4293/JSLS.2018.00036.
pmid: 30410300 |
[8] | 甘露, 段华. 子宫内膜干细胞参与子宫内膜修复的研究进展[J]. 中华妇产科杂志, 2015,50(10):795-797. doi: 10.3760/cma.j.issn.0529-567x.2015.10.020. |
[9] |
Zhu R, Gan L, Wang S, et al. A cohort study comparing the severity and outcome of intrauterine adhesiolysis for Asherman syndrome after first- or second-trimester termination of pregnancy[J]. Eur J Obstet Gynecol Reprod Biol, 2019,238:49-53. doi: 10.1016/j.ejogrb.2019.02.030.
doi: 10.1016/j.ejogrb.2019.02.030 pmid: 31082744 |
[10] |
Benor A, Gay S, DeCherney A. An update on stem cell therapy for Asherman syndrome[J]. J Assist Reprod Genet, 2020,37(7):1511-1529. doi: 10.1007/s10815-020-01801-x.
doi: 10.1007/s10815-020-01801-x pmid: 32445154 |
[11] |
Kou L, Jiang X, Xiao S, et al. Therapeutic options and drug delivery strategies for the prevention of intrauterine adhesions[J]. J Control Release, 2020,318:25-37. doi: 10.1016/j.jconrel.2019.12.007.
doi: 10.1016/j.jconrel.2019.12.007 pmid: 31830539 |
[12] |
March CM. Management of Asherman's syndrome[J]. Reprod Biomed Online, 2011,23(1):63-76. doi: 10.1016/j.rbmo.2010.11.018.
doi: 10.1016/j.rbmo.2010.11.018 pmid: 21549641 |
[13] |
Hooker AB, Muller LT, Paternotte E, et al. Immediate and long-term complications of delayed surgical management in the postpartum period: a retrospective analysis[J]. J Matern Fetal Neonatal Med, 2015,28(16):1884-1889. doi: 10.3109/14767058.2014.972356.
doi: 10.3109/14767058.2014.972356 pmid: 25308205 |
[14] |
Evans-Hoeker EA, Young SL. Endometrial receptivity and intrauterine adhesive disease[J]. Semin Reprod Med, 2014,32(5):392-401. doi: 10.1055/s-0034-1376358.
doi: 10.1055/s-0034-1376358 pmid: 24959821 |
[15] |
Dreisler E, Kjer JJ. Asherman′s syndrome: current perspectives on diagnosis and management[J]. Int J Womens Health, 2019,11:191-198. doi: 10.2147/IJWH.S165474.
doi: 10.2147/IJWH.S165474 pmid: 30936754 |
[16] |
Li C, Cai A, Sun C, et al. The study on the safety and efficacy of amnion graft for preventing the recurrence of moderate to severe intrauterine adhesions[J]. Genes Dis, 2020,7(2):266-271. doi: 10.1016/j.gendis.2019.03.003.
doi: 10.1016/j.gendis.2019.03.003 pmid: 32215296 |
[17] |
Mentula M, Männistö J, Gissler M, et al. Intrauterine adhesions following an induced termination of pregnancy: a nationwide cohort study[J]. BJOG, 2018,125(11):1424-1431. doi: 10.1111/1471-0528.15216.
doi: 10.1111/1471-0528.15216 pmid: 29532588 |
[18] | 马媛媛, 王文莉, 叶红. 胚物残留并发宫腔粘连的危险因素分析[J]. 国际妇产科学杂志, 2020,47(5):512-515. |
[19] |
Salazar CA, Isaacson K, Morris S. A comprehensive review of Asherman′s syndrome: causes, symptoms and treatment options[J]. Curr Opin Obstet Gynecol, 2017,29(4):249-256. doi: 10.1097/GCO.0000000000000378.
pmid: 28582327 |
[20] |
Smorgick N, Barel O, Fuchs N, et al. Hysteroscopic management of retained products of conception: meta-analysis and literature review[J]. Eur J Obstet Gynecol Reprod Biol, 2014,173:19-22. doi: 10.1016/j.ejogrb.2013.11.020.
doi: 10.1016/j.ejogrb.2013.11.020 pmid: 24332096 |
[21] |
AAGL Elevating Gynecologic Surgery. AAGL practice report: practice guidelines on intrauterine adhesions developed in collaboration with the European Society of Gynaecological Endoscopy (ESGE)[J]. Gynecol Surg, 2017,14(1):6. doi: 10.1186/s10397-017-1007-3.
doi: 10.1186/s10397-017-1007-3 pmid: 28603474 |
[22] |
Ludwin A, Ludwin I, Pityński K, et al. Role of morphologic characteristics of the uterine septum in the prediction and prevention of abnormal healing outcomes after hysteroscopic metroplasty[J]. Hum Reprod, 2014,29(7):1420-1431. doi: 10.1093/humrep/deu110.
doi: 10.1093/humrep/deu110 pmid: 24838703 |
[23] |
Bosteels J, Weyers S, Kasius J, et al. Anti-adhesion therapy following operative hysteroscopy for treatment of female subfertility[J]. Cochrane Database Syst Rev, 2015(11):CD011110. doi: 10.1002/14651858.CD011110.pub3.
doi: 10.1002/14651858.CD012267.pub2 pmid: 31743430 |
[24] |
Sharma JB, Sharma E, Sharma S, et al. Female genital tuberculosis: Revisited[J]. Indian J Med Res, 2018,148(Suppl):S71-S83. doi: 10.4103/ijmr.IJMR_648_18.
doi: 10.4103/ijmr.IJMR_648_18 pmid: 30964083 |
[25] | 段华, 甘露. 宫腔粘连诊治的现状与存在问题[J]. 实用妇产科杂志, 2017,33(10):721-723. |
[26] |
Chen Y, Liu L, Luo Y, et al. Prevalence and Impact of Chronic Endometritis in Patients With Intrauterine Adhesions: A Prospective Cohort Study[J]. J Minim Invasive Gynecol, 2017,24(1):74-79. doi: 10.1016/j.jmig.2016.09.022.
doi: 10.1016/j.jmig.2016.09.022 pmid: 27773811 |
[27] |
Papoutsis D, Georgantzis D, Daccò MD, et al. A rare case of Asherman′s syndrome after open myomectomy: sonographic investigations and possible underlying mechanisms[J]. Gynecol Obstet Invest, 2014,77(3):194-200. doi: 10.1159/000357489.
pmid: 24557451 |
[28] |
Khan Z, Goldberg JM. Hysteroscopic Management of Asherman's Syndrome[J]. J Minim Invasive Gynecol, 2018,25(2):218-228. doi: 10.1016/j.jmig.2017.09.020.
doi: 10.1016/j.jmig.2017.09.020 pmid: 29024798 |
[29] |
Matsubara S. A novel uterine stent for preventing intrauterine adhesion: not only gynecologic but also obstetric significance[J]. Ann Transl Med, 2020,8(10):614. doi: 10.21037/atm.2020.03.65.
doi: 10.21037/atm.2020.03.65 pmid: 32566551 |
[30] |
Zhu R, Duan H, Wang S, et al. Decision Tree Analysis: A Retrospective Analysis of Postoperative Recurrence of Adhesions in Patients with Moderate-to-Severe Intrauterine[J]. Biomed Res Int, 2019,2019:7391965. doi: 10.1155/2019/7391965.
doi: 10.1155/2019/7391965 pmid: 31915701 |
[31] |
Zhu R, Duan H, Gan L, et al. Comparison of Intrauterine Suitable Balloon and Foley Balloon in the Prevention of Adhesion after Hysteroscopic Adhesiolysis[J]. Biomed Res Int, 2018,2018:9494101. doi: 10.1155/2018/9494101.
pmid: 30533444 |
[32] |
Liu Z, Kong Y, Gao Y, et al. Revealing the interaction between intrauterine adhesion and vaginal microbiota using high throughput sequencing[J]. Mol Med Rep, 2019,19(5):4167-4174. doi: 10.3892/mmr.2019.10092.
doi: 10.3892/mmr.2019.10092 pmid: 30942434 |
[33] | 艾细雄, 李满超, 曾海涛, 等. 两种宫腔镜手术方式治疗宫腔粘连后的妊娠结局分析[J]. 国际妇产科学杂志, 2017,44(5):594-598. doi: 10.3969/j.issn.1674-1870.2017.05.026. |
[34] |
Zhao X, Zhang A, Gao B, et al. Cold scissors ploughing technique in hysteroscopic adhesiolysis: a comparative study[J]. Ann Transl Med, 2020,8(4):50. doi: 10.21037/atm.2019.11.136.
pmid: 32175344 |
[35] |
Di Guardo F, Della Corte L, Vilos GA, et al. Evaluation and treatment of infertile women with Asherman syndrome: an updated review focusing on the role of hysteroscopy[J]. Reprod Biomed Online, 2020,41(1):55-61. doi: 10.1016/j.rbmo.2020.03.021.
doi: 10.1016/j.rbmo.2020.03.021 pmid: 32444259 |
[36] |
Huang H, Zou L, Zhang A, et al. A preliminary study on a patented intrauterine stent in the treatment of recurrent intrauterine adhesions with poor prognosis[J]. Ann Transl Med, 2020,8(4):57. doi: 10.21037/atm.2020.01.77.
doi: 10.21037/atm.2020.01.77 pmid: 32175351 |
[37] | Huang CY, Chang WH, Cheng M, et al. Crosslinked Hyaluronic Acid Gels for the Prevention of Intrauterine Adhesions after a Hysteroscopic Myomectomy in Women with Submucosal Myomas: A Prospective, Randomized, Controlled Trial[J]. Life (Basel), 2020,10(5):67. doi: 10.3390/life10050067. |
[38] | 张博, 叶红. 宫形球囊和宫内节育器预防宫腔镜下子宫中隔切除术后宫腔粘连的比较[J]. 国际妇产科学杂志, 2018,45(5):593-595. doi: 10.3969/j.issn.1674-1870.2018.05.027. |
[39] |
Fei Z, Xin X, Fei H, et al. Meta-analysis of the use of hyaluronic acid gel to prevent intrauterine adhesions after miscarriage[J]. Eur J Obstet Gynecol Reprod Biol, 2020,244:1-4. doi: 10.1016/j.ejogrb.2019.10.018.
pmid: 31731019 |
[40] | 陈坤菊, 史小荣, 代晓琴. 宫腔粘连的预防方法研究进展[J]. 国际妇产科学杂志, 2017,44(5):576-580. |
[41] | 吕承晓, 段华. 间充质干细胞外泌体在女性生殖系统修复中的研究进展[J]. 中华妇产科杂志, 2020,55(9):645-648. doi: 10.3760/cma.j.cn112141-20191205-00659. |
[42] |
Santamaria X, Liu JH, Aghajanova L, et al. Should we consider alternative therapies to operative hysteroscopy for the treatment of Asherman syndrome?[J]. Fertil Steril, 2020,113(3):511-521. doi: 10.1016/j.fertnstert.2020.01.022.
doi: 10.1016/j.fertnstert.2020.01.022 pmid: 32111470 |
[43] | 张盼盼, 郝丽娟. 富血小板血浆在宫腔粘连中的应用及现状[J]. 国际妇产科学杂志, 2020,47(5):495-497,515. |
[44] |
Wang X, Liu L, Mou S, et al. Investigation of platelet-rich plasma in increasing proliferation and migration of endometrial mesenchymal stem cells and improving pregnancy outcome of patients with thin endometrium[J]. J Cell Biochem, 2018 Dec 3. doi: 10.1002/jcb.28014. Epub ahead of print.
pmid: 33590513 |
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