国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (2): 97-100.

• 综述 • 上一篇    下一篇

烟酰胺磷酸核糖转移酶与妇产科疾病

李彩虹,叶红   

  1. 443003 湖北省宜昌市，宜昌市中心人民医院三峡大学第一临床医学院妇产科
  • 收稿日期:2009-07-16 修回日期:1900-01-01 出版日期:2010-04-15 发布日期:2010-04-15
  • 通讯作者: 叶红

Nicotinamide Phosphoribosyl Transferase and Gynaecology and Obstetrics

LI Cai-hong, YE Hong   

  1. Department of Gynecology and Obstetrics, the Fisrt Clinical Medical College of Three Gorges University, Yichang 443002, Hubei Province, China
  • Received:2009-07-16 Revised:1900-01-01 Published:2010-04-15 Online:2010-04-15
  • Contact: YE Hong

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摘要： 烟酰胺磷酸核糖转移酶（Nampt）是一种结构高度保守的细胞因子,在最初克隆后近十年中Nampt并未引起关注。自2005年后，越来越多的研究发现，Nampt具有很多功能，其不仅是一种能模拟胰岛素作用的肽类激素，还是一种具有多种生物效应的脂肪因子。Nampt还具有酶的活性，参与细胞多种功能的调控，并与人类多种疾病和病理状态的发生有密切的关系，因而引起高度关注。就Nampt的特点及其与妇产科疾病的关系综述。

关键词: 烟酰胺磷酸核糖转移酶, 肽类激素, 脂肪因子, 酶

Abstract: Nicotinamide phosphoribosyltransferase （Nampt） is a cytokine with highly conserved structure. It received little notice during the first ten years. However, since 2005, Nampt has garnered an increasing attention due to accumulating evidence indicating that Nampt is a pleiotropic protein like peptide hormone, adipocytokine and nicotinamide phosphoribosyltransferase. Nampt is not only involved in regulating of cell multiple functions, but also implicated in the pathogenesis of a number of human diseases and conditions. This review will cover the current progress of the associations among Nampt and gynecologic and obstetric diseases or conditions.

Key words: Nicotinamide phosphoribosyltransferase, Peptide hormone, Adipocytokine, Enzyme