沉默信息调节因子2介导蛋白质去乙酰化与卵母细胞衰老

doi:10.12280/gjfckx.20230739

摘要/Abstract

摘要：

女性卵巢衰老远比机体其他器官衰老要早。随着人类生育年龄的推迟，卵巢衰老导致的不孕症所占比重越来越大。卵巢衰老是以卵母细胞的数量和质量下降为特征的一个自然生理过程。近年研究发现，沉默信息调节因子2（silence information regulator 2，SIRT2）介导非组蛋白和组蛋白去乙酰化，参与了卵母细胞衰老过程。哺乳动物卵泡中与年龄相关的SIRT2水平降低易致减数分裂缺陷，从而产生低质量的卵母细胞，影响妊娠结局。卵巢衰老是高龄不孕女性不可避免的自然生理过程，尽管目前辅助生殖技术为高龄不孕女性带来了福音，但低质量的卵母细胞也会影响辅助生殖技术的结局。综述SIRT2的定位、SIRT2与卵母细胞减数分裂的关系以及SIRT2在其中的主要作用，进一步介绍SIRT2介导间隙连接蛋白43（connexin 43，Cx43）、组蛋白H4第16位赖氨酸（H4K16）、α-微管蛋白（α-tubulin）、BUBR1和叉头框蛋白O3a（forkhead box O3a，FOXO3a）等蛋白质去乙酰化参与减数分裂过程所涉及的相关信号通路，为防治卵母细胞衰老提供新的思路。

关键词: 卵母细胞, 衰老, 抗衰老酶2, 蛋白质类, 乙酰化作用, 减数分裂

Abstract:

Female ovarian aging is much earlier than other organs of the body. With the age of human fertility delaying, the proportion of women experiencing infertility due to ovarian aging is increasing. Ovarian aging is a natural and physiological process characterized by a decline in the quantity and quality of oocytes. Recently, it was discovered that the silence information regulator 2 (SIRT2) mediated non-histone and histone deacetylation, which is involved in the process of oocyte cellular senescence. Age-related reduction of SIRT2 levels in mammalian follicles leads to meiosis defects, resulting in low-quality oocytes and affecting pregnancy outcomes. Ovarian aging is an inevitable natural and physiological process for senile infertile women. While human assisted reproductive technology has brought hope for infertile women at present, low-quality oocytes will also affect the outcome of assisted reproductive technology. In this paper, we will review the localization of SIRT2, its relationship with oocyte meiosis, and its primary role in it. In addition, SIRT2 mediates connexin 43 (Cx43), histone H4K16, α-tubulin, BUBR1, forkhead box O3a (FOXO3a), and other proteins deacetylation involved in the signaling pathway of meiosis, which provides a new idea for preventing oocyte aging.

Key words: Oocytes, Aging, Sirtuin 2, Proteins, Acetylation, Meiosis

金清美, 韩乔松, 梁竞男, 周悦, 孙振高, 宋景艳. 沉默信息调节因子2介导蛋白质去乙酰化与卵母细胞衰老[J]. 国际妇产科学杂志, 2024, 51(1): 99-104.

JIN Qing-mei, HAN Qiao-song, LIANG Jing-nan, ZHOU Yue, SUN Zhen-gao, SONG Jing-yan. SIRT2-Mediated Protein Deacetylation and Oocyte Senescence[J]. Journal of International Obstetrics and Gynecology, 2024, 51(1): 99-104.

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