国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (3): 300-301.

• 论著 • 上一篇    下一篇

PGP9.5在子宫内膜癌中的表达及其临床意义

孔祥菊 , 孔宪超   

  1. 150001 哈尔滨医科大学附属第二医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 孔宪超

Expression and Clinical Significance of Protein Gene Product 9.5 in Endometrial Cancer

KONG Xiang-ju，KONG Xian-chao   

  1. The Second Affiliated Hospital of Harbin Medical University，Harbin 150001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-06-15 Online:2012-06-15
  • Contact: KONG Xian-chao

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摘要： 目的：研究蛋白基因产物9.5（protein gene product 9.5，PGP9.5）在子宫内膜癌组织中的表达，并探讨其与子宫内膜癌的发生、发展和侵袭、转移的关系。方法：采用免疫组织化学二步法检测60例子宫内膜癌及10例正常子宫内膜中PGP9.5的表达。结果：在60例子宫内膜癌组织中有45例（75.0%）表达PGP9.5，而正常子宫内膜细胞中仅2例（20%）表达PGP9.5。PGP9.5的表达与子宫内膜癌的分期、分化程度及有无淋巴结转移有关（P＜0.05），与患者年龄、子宫内膜癌的组织学类型无关（P＞0.05）。结论：PGP9.5在子宫内膜癌侵袭及转移过程中可能发挥重要作用，PGP9.5的表达可作为肿瘤组织侵袭子宫内膜的一个分子标记物。

关键词: 子宫内膜肿瘤, 免疫组织化学, 癌基因蛋白质类, 癌基因, 基因表达

Abstract: Objective：To investigate the expression of protein gene product 9.5（PGP9.5）in endometrial cancer，and to find out the relationship between its expression and carcinogenesis，invasion and metastasis of endometrial carcinoma. Methods：The expression of PGP9.5 was detected by immunohistochemistry（Envision two steps ） in 60 patients of endometrial carcinoma and 10 patients of normal uterine tissues． Results：Of 60 endometrial cancer specimens examined，45 cases（75.0%）showed staining with PGP9.5 in most tumor cells，whereas PGP9.5 expression was detected only in 2 cases（20%） normal epithelium． The results of immunohistochemistry revealed that there were significantly correlations between the expression of PGP9.5 and the stages，the degree of differentiation，and the occurrence of lymph node metastasis respectively（P＜0.05）；but there were no correlation between the expression of PGP9.5 and age，histopathologic type（P＞0.05）. Conclusions：PGP9.5 may play an important role in the invasion and metastasis of endometrial cancer，and the invasion of endometrial cancer could be detected by PGP9.5，which may be a useful molecular marker．

Key words: Endometrial neoplasms, Immunohistochemistry, Oncogene proteins, Oncogenes, Gene expression