纳米微球在宫颈癌预防与治疗中的应用进展

doi:10.12280/gjfckx.20240820

摘要/Abstract

摘要：

宫颈癌作为一种常见的妇科恶性肿瘤，其发病率呈逐年上升趋势。传统的治疗方式如放疗、化疗和手术等仍存在严重的局限性。纳米医学的进步为宫颈癌的治疗带来了新的可能性，尤其是纳米技术的应用成为了研究的热点。纳米微球（nanoparticles，NPs）以其卓越的比表面积和高药物载荷能力以及多样化的材质选择和良好的生物相容性，成为了一种高效的纳米载体系统。NPs不仅能够承载多种治疗药物，还能通过精确控制药物释放的位置和时间，实现高剂量集中给药或长期缓释，从而提高药物疗效并减少不良反应。这些优势使得NPs在提升药物疗效方面显示出巨大的潜力，并在新的治疗策略中发挥关键作用。近年来，研究者们利用NPs构建了针对宫颈癌细胞的靶向输送系统，为宫颈癌的诊断和治疗带来了新的希望。

关键词: 纳米微球, 微球体, 宫颈肿瘤, 药物载体, 诊断, 治疗, 肿瘤微环境, 生物相容性, 精准医疗

Abstract:

Cervical cancer, as a common gynecological malignant tumor, its incidence rate is increasing year by year. Traditional treatment modalities such as radiotherapy, chemotherapy, and surgery still have serious limitations. Advances in nanomedicine have brought new possibilities for the treatment of cervical cancer, especially the application of nanotechnology has become a hot research topic. Nanoparticles (NPs) have become an efficient nanocarrier system due to their excellent specific surface area and high drug loading capacity, as well as diversified material choices and good biocompatibility. NPs are not only capable of carrying a variety of therapeutic drugs, but also can realize high-dose centralized drug delivery or long-term sustained-release by accurately controlling the location and time of drug release, thus improving drug efficacy and reducing adverse effects. These advantages make NPs show great potential in enhancing drug efficacy and play a key role in new therapeutic strategies. In recent years, researchers have utilized NPs to construct a targeted delivery system for cervical cancer cells, bringing new hope to the diagnosis and treatment of cervical cancer.

Key words: Nanoparticles, Microspheres, Uterine cervical neoplasms, Drug carriers, Diagnosis, Therapy, Tumor microenvironment, Biocompatibility, Precision medicine

张野, 陈巧云, 赵佳怡, 陈璐, 刘建荣. 纳米微球在宫颈癌预防与治疗中的应用进展[J]. 国际妇产科学杂志, 2025, 52(1): 8-12.

ZHANG Ye, CHEN Qiao-yun, ZHAO Jia-yi, CHEN Lu, LIU Jian-rong. Progress in the Application of Nanoparticles in the Prevention and Treatment of Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2025, 52(1): 8-12.

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