凝血酶敏感蛋白-1在子痫前期发病中的作用

doi:10.12280/gjfckx.20250051

摘要/Abstract

摘要：

子痫前期（preeclampsia，PE）是妊娠期特有的疾病，是孕产妇死亡和新生儿预后不良的主要原因之一。目前PE的病因及发病机制尚未完全阐明，滋养细胞侵袭不足导致子宫螺旋动脉重塑障碍、胎盘发育异常以及血管内皮细胞障碍等是PE发病的重要因素。凝血酶敏感蛋白-1（thrombospondin-1，TSP-1）是由人体内多种细胞分泌的一种多结构域、多功能的细胞外基质糖蛋白，TSP-1的多结构域可与多种细胞表面受体分子相互作用，参与调节多种生理和病理过程（如血管生成、炎症反应、血小板活化、细胞侵袭、免疫反应等）以及高血压、高脂血症等疾病的发生发展。近年研究表明，TSP-1在PE患者胎盘及母体血清中表达升高，其可能是PE发病的原因之一。综述TSP-1在PE发生发展中的作用，为PE的诊断和治疗提供新思路。

关键词: 先兆子痫, 凝血酶敏感蛋白1, 内皮, 血管, 氧化性应激, 新生血管化, 生理性

Abstract:

Preeclampsia (PE) is a pregnancy-specific disorder and one of the leading causes of maternal mortality and neonatal morbidity. To date, the etiology and pathogenesis of PE remain incompletely elucidated. Insufficient trophoblast invasion leading to impaired uterine spiral artery remodeling, aberrant placental development, and vascular endothelial dysfunction are key factors contributing to the pathogenesis of PE. Thrombospondin-1 (TSP-1), a multi-domain and multi-functional extracellular matrix glycoprotein secreted by various human cells, interacts with multiple cell surface receptors and plays a role in regulating diverse physiological and pathological processes, including angiogenesis, inflammatory responses, platelet activation, cellular invasion, and immune responses, and the occurrence and development of hypertension and hyperlipidemia. Recent studies have demonstrated elevated expression levels of TSP-1 in both the placenta and maternal serum of patients with PE. Consequently, TSP-1 may be one of the contributing factors to the pathogenesis of PE. This review aims to summarize the role of TSP-1 in the pathophysiology of PE, providing new ideas for its diagnosis and treatment.

Key words: Pre-eclampsia, Thrombospondin 1, Endothelium, vascular, Oxidative stress, Neovascularization, physiologic

任晟, 王永红. 凝血酶敏感蛋白-1在子痫前期发病中的作用[J]. 国际妇产科学杂志, 2025, 52(3): 275-279.

REN Sheng, WANG Yong-hong. The Role of Thrombospondin-1 in the Pathogenesis of Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2025, 52(3): 275-279.

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