血清铁及铁死亡在子痫前期中的研究进展

doi:10.12280/gjfckx.20250159

摘要/Abstract

摘要：

子痫前期是妊娠期严重威胁母婴健康的特有疾病，其发病机制复杂。铁在维持机体正常生理功能中不可或缺，其参与氧运输、能量代谢以及多种酶的合成。当血清铁水平异常时，会引发一系列生理紊乱。铁死亡是一种铁离子依赖、以脂质过氧化为特征的新型程序性细胞死亡方式。研究发现，子痫前期患者血清铁代谢失衡，血清铁水平升高，可能通过引发铁死亡致使胎盘滋养细胞和血管内皮细胞受损，导致滋养细胞浸润不足、子宫螺旋动脉重塑障碍，进而使胎盘功能受损，可能导致不良妊娠结局。血清铁代谢异常和铁死亡可能是子痫前期发病的重要机制之一，深入探究其间具体机制，有望为子痫前期的早期诊断、病情监测及治疗提供新的思路与靶点。

关键词: 铁, 铁死亡, 先兆子痫, 脂质过氧化作用, 炎症, 氧化性应激

Abstract:

Preeclampsia is a pregnancy-specific disorder that severely threatens the maternal and fetal health, with a complex pathogenesis. Iron is indispensable for maintaining normal physiological functions, participating in oxygen transport, energy metabolism, and the synthesis of various enzymes. Abnormal serum iron levels can trigger a series of physiological disorders. Ferroptosis is a novel type of iron-dependent programmed cell death and characterized by lipid peroxidation. Studies have found that in patients with preeclampsia, exhibiting dysregulated serum iron metabolism and an increase in serum iron levels. This process may lead to damage to placental trophoblasts cells and vascular endothelial cells by inducing ferroptosis, resulting in insufficient trophoblast cell invasion and impaired remodeling of uterine spiral arteries, which ultimately impairs placental function and leads to adverse pregnancy outcomes. Abnormal serum iron metabolism and ferroptosis may represent key mechanisms in preeclampsia pathogenesis. Further investigation of the specific mechanisms is expected to provide novel insights and therapeutic targets for the early diagnosis, condition monitoring, and treatment of preeclampsia.

Key words: Iron, Ferroptosis, Pre-eclampsia, Lipid peroxidation, Inflammation, Oxidative stress

陈怡冰, 涂静妍, 唐一铭, 林瀟阳, 刘焰铎, 韩晴. 血清铁及铁死亡在子痫前期中的研究进展[J]. 国际妇产科学杂志, 2025, 52(4): 361-365.

CHEN Yi-bing, TU Jing-yan, TANG Yi-ming, LIN Xiao-yang, LIU Yan-duo, HAN Qing. Research Progress on Serum Iron and Ferroptosis in Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2025, 52(4): 361-365.

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