国际妇产科学杂志

国际妇产科学杂志 ›› 2026, Vol. 53 ›› Issue (1): 117-120.doi: 10.12280/gjfckx.20251171

• 产科生理及产科疾病: 病例报告 • 上一篇    

母源性新生儿一过性重症肌无力一例

王鹏源, 衣凤鑫, 迟云倩, 张子涵, 王云鹤, 张星颖, 郝薇()   

  1. 250000 济南，山东中医药大学第二临床医学院（王鹏源，衣凤鑫，张星颖）；山东第一医科大学附属省立医院新生儿科（迟云倩，张子涵，王云鹤，郝薇）
  • 收稿日期:2025-10-17 出版日期:2026-02-15 发布日期:2026-03-11
  • 通讯作者: 郝薇 E-mail:haowei12875@163.com
  • 基金资助:
    2023年山东省本科高校教学改革研究项目(M2023116)

Transient Neonatal Myasthenia Gravis of Maternal Origin: A Case Report

WANG Peng-yuan, YI Feng-xin, CHI Yun-qian, ZHANG Zi-han, WANG Yun-he, ZHANG Xing-ying, HAO Wei()   

  1. Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250000, China (WANG Peng-yuan, YI Feng-xin, ZHANG Xing-ying); Department of Neonatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China (CHI Yun-qian, ZHANG Zi-han, WANG Yun-he, HAO Wei)
  • Received:2025-10-17 Published:2026-02-15 Online:2026-03-11
  • Contact: HAO Wei E-mail:haowei12875@163.com

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摘要：

新生儿一过性重症肌无力（transient neonatal myasthenia gravis，TNMG）起病隐匿，临床表现呈现非特异性，易被误诊，主要以母体重症肌无力（myasthenia gravis，MG）的并发症出现。报告1例母源性TNMG患儿，主要表现为呼吸困难、肌张力低下、吞咽困难和哭声微弱。患儿乙酰胆碱受体（acetylcholine receptor，AChR）抗体阳性，结合临床表现及母亲MG病史，确诊为TNMG。经机械通气、静脉注射人免疫球蛋白、溴吡斯的明及抗感染等综合治疗后，患儿症状逐渐缓解，入院第30天治愈出院。随访至6个月龄，患儿生长发育正常。TNMG的早期识别至关重要，经个体化综合干预后，多数患者预后情况良好。

关键词: 婴儿，新生, 重症肌无力，新生儿, 受体，胆碱能, 诊断, 治疗, 预后

Abstract:

Transient neonatal myasthenia gravis (TNMG) has an insidious onset, and its clinical manifestations are non-specific, making it easily misdiagnosed. It mainly occurs as a complication of maternal myasthenia gravis (MG). A case of a child with maternal TNMG is reported. The main manifestations were dyspnea, hypotonia, dysphagia, and a weak cry. The child was positive for acetylcholine receptor (AChR) antibodies. Based on the clinical manifestations and the mother's history of MG, the child was diagnosed with TNMG. After comprehensive treatment including mechanical ventilation, intravenous injection of human immunoglobulin, pyridostigmine bromide, and anti-infection therapy, the child's symptoms gradually improved. The child was cured and discharged on the 30th day after admission. During the follow-up until 6 months of age, the child's growth and development were normal. Early identification of TNMG is crucial. After individualized comprehensive intervention, the prognosis of most patients is good.

Key words: Infant, newborn, Myasthenia gravis, neonatal, Receptors, cholinergic, Diagnosis, Therapy, Prognosis