国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (1): 36-39.

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MicroRNAs与多囊卵巢综合征及胰岛素分泌的相关研究进展

董 哲,杨冬梓   

  1. 510120 广州,中山大学孙逸仙纪念医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 杨冬梓

Recent Advances in MicroRNAs with Polycystic Ovary Syndrome and Insulin Secretion

DONG Zhe，YANG Dong-zi   

  1. Department of Obstetrics and Gynecology，Sun Yat-Sen Memorial Hospital，Sun Yat-Sen University，Guangzhou 510120，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-02-15 Online:2012-02-15
  • Contact: YANG Dong-zi

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摘要： MicroRNAs（miRNAs）是近年发现的一类通过抑制靶基因翻译来调控细胞发育、分化、增殖、凋亡及疾病发生发展等多种过程的小分子非编码单链RNA。多囊卵巢综合征（PCOS）是育龄期女性最常见的内分泌疾病之一，并与高胰岛素血症、胰岛素抵抗关系密切。目前PCOS的病因、发病机制及其与高胰岛素血症、胰岛素抵抗之间的关系仍不十分清楚。而miRNAs作为在各种生命过程中均具有强大作用的转录后调控因子，为这些问题的研究开辟了新的思路。综述miRNAs与PCOS及胰岛素分泌相关的研究进展。

关键词: 微RNAs, 多囊卵巢综合征, 高胰岛素血症, 胰岛素抗药性

Abstract: MicroRNAs are a group of non-coding small RNAs，participanting in the processes of cell development，differentiation， proliferation，apoptosis and pathogenesis by inhibiting the translationes of target genes mRNA. Polycystic ovary syndrome（PCOS） is one of the most common endocrinologic disorders and has close relationship with hyperinsulinemia and insulin resistance（IR）. So far，the pathology of PCOS and the relationship between PCOS and hyperinsulinemia/IR are still unclear. MicroRNAs which play important roles in post-transcriptional regulation could lead a new way for these researches. Therefore，the recent advances in studies on microRNAs with PCOS or insulin secretion were reviewed in this article.

Key words: MicroRNAs, Polycystic ovary syndrome, Hyperinsulinism, Insulin resistance