国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (1): 60-64.

• 综述 • 上一篇    下一篇

孕酮诱导的封闭因子对妊娠免疫的调节

张越，林其德，张殊

  

  1. 200127 上海交通大学医学院附属仁济医院妇产科 上海市妇科肿瘤重点实验室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-02-15 发布日期:2015-02-15

Progesterone-induced Blocking Factor Regulates Pregnancy Immunity

ZHANG Yue，LIN Qi-de，ZHANG Shu   

  1. Department of Obstetrics and Gynecology，Renji Hospital，School of Medicine，Shanghai Jiao Tong University，Key Subject of Shanghai Education Committee，Shanghai Laboratory of Gynecologic Oncology，Shanghai 200127，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-02-15 Online:2015-02-15

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摘要： 妊娠稳态受免疫细胞因子和免疫细胞的调节，母胎免疫异常可导致妊娠终止。孕激素可诱导淋巴细胞产生孕酮诱导的封闭因子（progesterone-induced blocking factor，PIBF），促使Th2型细胞因子分泌，诱导Th1/Th2平衡向Th2型细胞因子偏倚；抑制自然杀伤（NK）细胞活性；降低花生四烯酸分泌；促使不对称抗体产生等免疫机制维持妊娠。流产和早产患者PIBF水平明显低于正常妊娠妇女。采用酶联免疫吸附测定、免疫组化、蛋白质印迹和流式细胞术等方法能测定人外周血淋巴细胞、血清及尿液中PIBF水平。孕酮及其衍生物能增加PIBF的分泌维持妊娠，预防流产发生。综述PIBF在妊娠期的免疫调节功能以及研究进展。

关键词: 妊娠, 流产, 免疫活性, 孕酮, 孕酮诱导的封闭因子

Abstract: Immune factors and immunocytes play critical roles in the maintenance of pregnancy，abnormal immune response of the mother toward the fetus causes abortion. One kind of protein called progesterone-induced blocking factor （PIBF） is derived by lymphocytes of pregnant women. PIBF increases Th2 type cytokine production，induces Th1/Th2 balance bias to Th2 type cytokine，inhibits NK cells activity，reduces arachidonic acid release and promotes the synthesis of asymmetric antibodies to mediate the immunomodulatory and anti-abortive effects of progesterone. Women with threatened abortion or pre-term labour display reduced concentrations of PIBF than women with viable pregnancy. PIBF in peripheral blood lymphocytes，blood serum，and urine can be tested with ELISA，immunohistochemistry，western blot and flow cytometry. Progesterone and dydrogesterone might improve pregnancy successfully by inducing secretion of PIBF. In this review，we summarise the regulation of PIBF in pregnancy immunity.

Key words: Pregnancy, Abortion, Immunocompetence, Progesterone, Progesterone-induced blocking factor