国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (3): 294-297.

• 综述 • 上一篇    下一篇

雌激素激活端粒酶抗衰老机制研究进展

岑加萍，张红艳，刘元伟，邓妙，张治芬   

  1. 310006 杭州市第一人民医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-06-15 发布日期:2015-06-15
  • 通讯作者: 张治芬

Research Progress of Estrogen Regulation of Telomerase Activity in Anti-aging

CEN Jia-ping，ZHANG Hong-yan，LIU Yuan-wei，DENG Miao，ZHANG Zhi-fen   

  1. Department of Obstetrics and Gynecology，Hangzhou First People′s Hospital，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-06-15 Online:2015-06-15
  • Contact: ZHANG Zhi-fen

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摘要： 端粒（telomere）是位于真核细胞染色体末端的DNA重复序列，端粒的缺失会使细胞逐渐失去增殖能力，导致细胞的衰老和死亡。端粒酶（telomerase）具有催化端粒DNA合成的能力，能帮助维持端粒的长度。人端粒酶逆转录酶（human telomerase reverse transcriptase，hTERT）可以激活端粒酶的活性，延长染色体末端DNA，维持基因组的稳定性和完整性从而延缓细胞衰老。研究表明雌激素、端粒、端粒酶与机体的衰老存在密切的关系，雌激素可通过多种机制激活端粒酶的活性延缓细胞衰老，并通过影响hTERT基因启动子激活端粒酶。综述雌激素影响hTERT基因水平上调端粒酶活性从而发挥抗衰老的机制。

关键词: 雌激素类, 端粒, 端粒, 末端转移酶, 催化域, 衰老

Abstract: Telomeres are located at the ends of eukaryotic chromosomes DNA repeat sequence. The capacity of cell proliferation will gradully lose result from telomeres deletion and result in cellular senescence and death. Telomerase has the ability to catalyze the synthesis of telomeric DNA, which can help maintain telomere in length. Human telomerase catalytic subunit (hTERT) can activate telomerase activity, extend the ends of chromosomes DNA, maintain the stability and integrity of the genome thus to extend the cell ageing. Studies have confirmed the existence of a close relationship among estrogen, telomeres, telomerase and body aging, and estrogen can activate telomerase through various mechanisms to delay aging and influence the promoter activity of hTERT. In this paper, the mechanism of estrogen regulated telomerase activity anti-ageing were been summarized.

Key words: Estrogens, Telomere, Telomerase, Catalytic domain, Aging