国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (3): 298-300.

• 综述 • 上一篇    下一篇

PAI-1基因启动子区4G/5G基因多态性与多囊卵巢综合征

刘元伟，邓妙，岑加萍，张红艳，张治芬   

  1. 310006 杭州市第一人民医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-06-15 发布日期:2015-06-15
  • 通讯作者: 张治芬

4G/5G Polymorphism in Promoter Region of PAI-1 Gene and Polycystic Ovary Syndrome

LIU Yuan-wei，DENG Miao，CEN Jia-ping，ZHANG Hong-yan，ZHANG Zhi-fen   

  1. Department of Obstetrics and Gynecology，Hangzhou First People′s Hospital，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-06-15 Online:2015-06-15
  • Contact: ZHANG Zhi-fen

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摘要： 多囊卵巢综合征（polycystic ovary syndrome，PCOS）是育龄期女性最常见的生殖内分泌疾病，病因迄今不明，具有高度的家族聚集性，提示遗传因素在其发病中起重要作用。纤溶酶原激活物抑制剂1（plasminogen activator inhibitor-1，PAI-1）是纤溶系统的主要生理抑制剂，大量研究表明PAI-1基因启动子区4G/5G基因多态性可通过升高血浆PAI-1水平及活性影响胰岛素的敏感性，参与胰岛素抵抗（insulin resistance，IR）的形成。IR是PCOS主要的病理生理机制，与PCOS患者肥胖、自然流产等的发生密切相关，提示PAI-1基因启动子区4G/5G基因多态性与PCOS的发生、发展可能有着密切的关系。因此，PAI-1基因启动子区4G/5G基因多态性与PCOS的相关研究也成为近年研究热点，主要涉及PCOS的发病、肥胖、IR、自然流产及远期并发心血管疾病等，但相关结论尚存争议。

关键词: 多囊卵巢综合征, 纤溶酶原激活物抑制物1, 胰岛素抗药性, 多态现象, 遗传

Abstract: Polycystic ovary syndrome（PCOS） is the most common reproductive endocrine disorders，affecting those women of childbearing age，but its pathogenic factors is unknown so far. PCOS has a high degree of familial aggregation，indicating genetic factors play an important role in the pathogenesis. Plasminogen activator inhibitor-1（PAI-1）is the main physiological inhibitor of fibrinolytic system，and a large number of studies have shown that 4G/5G polymorphism in promoter region of PAI-1 gene can effect insulin sensitivity by elevating the level and activity of plasma PAI-1，involved in the formation of insulin resistance (IR). IR is the mainly pathophysiology of PCOS，closely related to obesity and spontaneous abortion of PCOS，prompting that PAI-1 gene 4G/5G polymorphism may have a close relationship with the occurrence and development of PCOS. Therefore,the related research about 4G/5G polymorphism in promoter region of PAI-1 gene and PCOS has become a hot spot in recent years, mainly involved the pathogenesis，obesity，IR，spontaneous abortion and the forward complicated with cardiovascular disease of PCOS，but the conclusion is still controversial.

Key words: Polycystic ovary syndrome, Plasminogen activator inhibitor 1, Insulin resistance, Polymorphism, genetic