国际妇产科学杂志

国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (3): 282-286.

• 综述 • 上一篇    下一篇

糖皮质激素诱导的肿瘤坏死因子受体在Tregs介导下的免疫耐受作用的研究进展

谭燕，王晨虹   

  1. 529000 广东省江门市中心医院产科（谭燕）；深圳市妇幼保健院（王晨虹）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-06-22 发布日期:2016-06-22
  • 通讯作者: 王晨虹

Progress on Glucocorticoid-induced TNF Receptor Mediated by Tregs in Immune Tolerance

TAN Yan，WANG Chen-hong   

  1. Department of Obstetrics，The Central Hospital of Jiangmen City，Jiangmen 529000，Guangdong Province，China（TAN Yan）；Shenzhen Maternal and Child Health Care Hospital，Shenzhen 518028，Guangdong Province，China（WANG Chen-hong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-06-22 Online:2016-06-22
  • Contact: WANG Chen-hong

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摘要： 糖皮质激素诱导的肿瘤坏死因子受体（glucocorticoid-induced TNF receptor，GITR）是胸腺和外周淋巴器官中调节性T细胞（regulatory T cells，Tregs）表达的一个重要功能分子，在Tregs的分化和扩张中起关键性作用，是人类Tregs非常有效的标记物，在Tregs的免疫调节中发挥重要作用。GITR具有许多重要的生物学活性，包括细胞的增殖、分化、存活和凋亡等，其相互作用可打破Tregs介导的免疫耐受，诱发或加重自身免疫性疾病，如哮喘、糖尿病、关节炎、系统性红斑狼疮等。妊娠选择了免疫耐受这一基本机制，Tregs在保护胎儿免受母体免疫攻击方面发挥重要作用，许多研究已表明：在妊娠期间中断Tregs的相互作用会导致胎儿特异性抗原的产生，继而导致不良妊娠结局。综述GITR在Tregs介导下的免疫耐受作用。

关键词: 糖皮质激素类诱导TNFR相关蛋白质, 受体, 肿瘤坏死因子, T淋巴细胞, 调节性, 免疫耐受, 自身免疫, 妊娠, 糖皮质激素类诱导TNFR相关蛋白质, 受体, 肿瘤坏死因子, T淋巴细胞, 调节性, 免疫耐受, 自身免疫, 妊娠

Abstract: Glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important functional molecular of regulatory T cells (regulatory T cells，Tregs) expressed in thymus and peripheral lymphoid organs. Numerous studies have shown the key role of GITR in differentiation and extension of Tregs. Furdermore，GITR is an effective marker of Tregs and play an important role in immune regulation. GITR has many important biological activities，including cell proliferation，differentiation，survival and apoptosis，etc. The interactions of them can break immune tolerance mediated by Tregs，induce or aggravate autoimmune diseases，such as asthma，diabetes，arthritis and systemic lupus erythematosus，etc. All pregnancies comply with the rules of immune tolerance，Tregs play an important role in protecting fetus from immune attack. Many studies have shown that interruption of the interaction in Tregs during the pregnancy can lead to the generation of fetal specific antigen，which in turn will lead to adverse pregnancy outcome. Now a review will be made here on GITR mediated by Tregs in immune tolerance.

Key words: Glucocorticoid-induced TNFR-related protein, Receptors, tumor necrosis factor, T-lymphocytes, regulatory, Immune tolerance, Pregnancy, Glucocorticoid-induced TNFR-related protein, Receptors, tumor necrosis factor, T-lymphocytes, regulatory, Immune tolerance, Autoimmunity, Pregnancy