国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (3): 262-264.

• 综述 • 上一篇    下一篇

细胞角蛋白与P16INK4a在宫颈癌前病变及宫颈癌中的研究进展

刘 微, 瞿全新   

  1. 300192 天津医科大学一中心临床学院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-06-15 发布日期:2012-06-15

The Advances of Cytokeratins and P16INK4a in Cervical Intraepithelial Neoplasia and Cervical Cancer

LIU Wei，QU Quan-xin   

  1. The First Centre Clinical College of Tianjin Medical University，Tianjin 300192，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-06-15 Online:2012-06-15

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摘要： 宫颈癌是常见的妇科恶性肿瘤之一，且近年来年轻患者有明显上升的趋势。子宫颈上皮内瘤变（CIN）是与子宫颈浸润癌密切相关的一组癌前病变，也是宫颈癌防治的重要阶段。从宫颈癌前病变发展成宫颈癌是一个较长时间的过程，有效的诊断和治疗CIN是预防宫颈癌的最佳途径。有研究认为，细胞角蛋白17（CK17）是宫颈干细胞的标记物，反映了一种细胞化生由不成熟向成熟转化的现象。CK8、CK17表达水平与宫颈上皮内瘤样病变程度及宫颈癌有关，分析CK8、CK17表达水平可作为预测宫颈癌高危患者的指标。P16INK4a异常甲基化与宫颈癌的临床分期及病理分级有关，在晚期及恶性程度较高的组织中，其活性明显增强。综述细胞角蛋白与P16INK4a在宫颈癌前病变及宫颈癌发生及发展中的研究进展。

关键词: 宫颈上皮内瘤样病变, 宫颈肿瘤, 角蛋白质类, P16INK4a

Abstract: The cervical cancer is one of the common gynecologic malignant tumors，and in recent years the amount of the young patients has obviously risen. The cervical intraepithelial neoplasia（CIN）is closely related to cervical invasive carcinoma as a group of precancerous lesions，which is also an important stage in the cervical cancer progression. The proceeding from cervical intraepithelial neoplasia（CIN）to cervical cancer is a long period，so the effective diagnosis and treatments of CIN are the best way to prevent the cervical cancer. Some studies claimed that CK17 was a marker of the cervical stem cells and reflected the phenomena from immature to mature of cervical cell metaplasia. The expression level of CK8 and CK17 is related to the degree of CIN and cervical cancer. Analysis the expression level of CK8，CK17 can be as a predictor for the high-risk cases.The P16INK4a ′s abnormal methylation is related to the the clinical stages and pathological classification of cervical cancer. In terminal and high malignant degree′s tissues，its activities is obviously enhanced. This review will discuss the advances of cytokeratins and P16INK4a in the cervical cancer and CIN in terms of occurrence and development .

Key words: Cervical intraepithelial neoplasia, Uterine cervical neoplasms, Keratins, P16INK4a