国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (5): 440-442.

• 综述 • 上一篇    下一篇

人附睾蛋白4在子宫内膜癌中临床价值的评估

张 晶,王赞宏   

  1. 030001 太原，山西医科大学附属大医院（张 晶）；山西医学科学院山西大医院妇产科（王赞宏）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-10-15 发布日期:2013-10-15
  • 通讯作者: 王赞宏

Evaluation of Clinical Value of Human Epididymis Protein 4 in Patients with Endometrial Cancer

ZHANG Jing，WANG Zan-hong   

  1. Da Yi Hospital of Shanxi Medical University，Taiyuan 030001，China（ZHANG Jing）；Department of Gynecology，Shanxi Academy of Medical Sciences，Shanxi Da Yi Hospital，Taiyuan 030032，China（WANG Zan-hong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-10-15 Online:2013-10-15
  • Contact: WANG Zan-hong

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摘要： 子宫内膜癌是女性生殖系统常见的恶性肿瘤，是导致女性死亡的重要因素。近年来世界范围内发病率明显上升，且趋于年轻化，早期诊断和治疗对改善患者预后至关重要。但截至目前仍缺乏敏感而特异的血清学标记物。近来研究发现，人附睾蛋白4（HE4）在子宫内膜癌组织中高表达，而在正常内膜组织及内膜良性病变中不表达或低表达，HE4是否可作为子宫内膜癌的早期诊断和预后的指标备受关注。现就HE4在子宫内膜癌的诊断和预后评估等方面的临床应用价值进行综述。

关键词: 肿瘤标记, 生物学, 子宫内膜肿瘤, 敏感性与特异性, CA-125抗原, 人附睾蛋白4

Abstract: Endometrial cancer is one of the most common gynecologic malignancies，and it remains one of the most important causes of mortality in women worldwide. In recent years，the incidence of endometrial cancer has been increased and the age of onset of endometrial cancer has decreased. So it is essential for early diagnosis and treatment of endometrial cancer，but until now，there is still lack of sensitive and specific serological markers. Recent studies have demonstrated that human epididymis protein 4（HE4） was highly expressed in endometrial cancer，and lowly expressed in normal endometrium and benign endometrial lesions. Studies focus on whether HE4 can be used as endometrial cancer early diagnosis and prognosis marker now. This review will briefly summarize the clinical value of HE4 in diagnosis and prognosis of endometrial cancer.

Key words: Tumor markers, biological, Endometrial neoplasms, Sensitivity and specificity, CA-125 antigen, Human epididymis protein 4