国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (5): 443-445.

• 综述 • 上一篇    下一篇

宫颈癌变进展中人乳头瘤病毒甲基化的研究

胡元晶, 曲芃芃   

  1. 300100 天津市中心妇产科医院妇瘤科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-10-15 发布日期:2013-10-15
  • 通讯作者: 曲芃芃

Methylation Alterations of Human Papillomavirus in Cervical Carcinogenesis

HU Yuan-jing，QU Peng-peng   

  1. Department of Gynecologic Oncology，Tianjin Central Hospital of Gynecology Obstetrics，Tianjin 300100，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-10-15 Online:2013-10-15
  • Contact: QU Peng-peng

PDF (PC)

4847

被引次数

1

摘要： 高危型人乳头瘤病毒（HPV）持续感染是宫颈癌发生的直接原因，然而HPV感染后多数可被宿主免疫机制清除，只在部分病例中HPV感染持续存在并与宿主细胞DNA整合，导致宿主细胞癌变。HPV表观遗传学的改变在病毒整合及致宿主细胞癌变中起一定作用。对目前有关HPV表观遗传学特点在影响HPV自身表达和宫颈病变进展中作用的文献加以综述，了解HPV DNA甲基化状态在宫颈癌发生、发展中的作用。HPV基因表观遗传学状态有可能成为临床诊断和判断预后的分子标记物。

关键词: 宫颈肿瘤, 人乳头瘤病毒16, DNA甲基化, 基因沉默

Abstract: The pathogeny of cervical cancer is persistent high-risk HPV infection. However，most of HPV infection can be cleared by the host′s immune system，only minority will intergrate into the host′s DNA and transform the epithelial host cells to malignant cells. Together with further genetic and epigenetic alterations of HPV play a role in virus DNA intergration and carcinogenisis. This paper reviewed how HPV epigenetic alterations can affect the expression of papillomaviral as well as the relation to the multistep process of carcinogenesis. HPV DNA methylation level affected the carcinogenisis and progression of cervical cancer. Biomarker roles in clinical diagnosis and prognosis might be assigned to the epigenetic pattern of HPV genes.

Key words: Uterine cervical neoplasms, Human papillomavirus 16, DNA methylation, Gene silencing