Abstract:

Adverse pregnancy mainly includes early recurrent abortion, abnormal fetal development and so on. Adverse pregnancy imposes a heavy burden on families and society. Reducing birth defects is an important task for obstetricians and gynecologists. The cause of adverse fertility is complex, which is the result of the combination of genetic and environmental factors. Folic acid is a hot research topic that leads to adverse pregnancy. Folic acid deficiency or utilization disorder is a well-established cause of fetal neural tube defects. Folic acid deficiency may also be associated with recurrent abortion, male sterility, and other birth defects such as cleft lip and palate, congenital heart disease and Down syndrome. Although there are many relevant studies, the specific pathogenesis is still unclear. In recent years, many studies have elucidated the correlation between folic acid deficiency and adverse fertility from the aspects of gene and histone modified epigenetics. Based on the relevant literature in recent years, the paper reviews folic acid transport absorption, folic acid metabolism and related enzyme polymorphism, folic acid deficiency leading to various adverse fertility and its pathogenesis, to lay a theoretical foundation for further research on the relationship between them.

Key words: Folic acid, Metabolism, Abortion,spontaneous, Infertility,male, Congenital abnormalities