Vitamin B12 Deficiency and Adverse Pregnancy Outcomes

doi:10.12280/gjfckx.20211141

Abstract

Abstract:

Vitamin B12 is an essential water-soluble vitamin. As a coenzyme of methionine synthase and l-methylmalonyl-CoA mutase, it participates in folic acid, methionine cycle and DNA synthesis, while it can reduce blood homocysteine concentration, which plays an important physiological role during pregnancy. Due to the increased maternal demand for vitamin B12 during pregnancy, if accompanied by insufficient intake, malabsorption or malutilization, it is easy to cause vitamin B12 deficiency during pregnancy, which can lead to gestational diabetes mellitus, premature birth, miscarriage, low birth weight, neural tube defects and other pregnancy complications, but the pathogenic mechanism is not fully understood. This article reviews the research progress of vitamin B12 deficiency and adverse pregnancy outcomes, and provides ideas for clinical diagnosis and treatment.

Key words: Vitamin B 12 deficiency, Folic acid, Hyperhomocysteinemia, Pregnancy complications, Pregnancy outcome

WANG Tian-jing, CHEN Dan-qing. Vitamin B12 Deficiency and Adverse Pregnancy Outcomes[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 420-425.

Figures/Tables 1

References 27

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