Abstract:

Hypertensive disorders complicating pregnancy(HDCP) is a group of diseases with pregnancy and high blood pressure at the same time, which is unique during the gestation period. This group of diseases are characterized by high blood pressure, proteinuria and edema. It can lead to higher risk of adverse conditions such as heart failure, eclampsia, postpartum hemorrhage or placental abruption in pregnant women. And it is also accompanied with multiple organ damage, affect mother and her baby′s health seriously. Fetal growth restriction (FGR) is a failure of fetus to reach its growth potential due to genetical or maternal placenta environmental factors. FGR is the second reason of perinatal death in China, with an incidence of 6.39%. The incidence of HDCP and FGR is high to 20%-30%, however, the pathological mechanism of the relationship between them is not clear. Existing studies generally believe that hypertension during pregnancy combined with fetal intrauterine growth restriction, may be affected by vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and many other cytokines, which are related to placental insufficiency.

Key words: Hypertension, pregnancy-induced, Fetal growth restriction, Fetal development, Vascular endothelial growth factors, Placenta growth factor, Soluble fms-like tyrosine kinase-1, Placenta