Progress in the Clinical Application of PD-1/PD-L1 Inhibitor in the Treatment of Ovarian Neoplasms

doi:10.12280/gjfckx.20210173

Abstract

Abstract:

Ovarian neoplasm has the highest mortality among female reproductive system tumors. The methods of treating ovarian cancer involve surgery combined with radiotherapy, chemotherapy and targeted therapy, yet there is no significant improvement in the survival rate of patients. Immunotherapy is a new strategy for malignant ovarian tumors and aims to boost the capacity of the immune system to recognize and attack tumor cells. Some of them have been proven to show effects, among which programmed death-1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint inhibitors had been applied to improve the prognosis of advanced, recurrent platinum-sensitive or platinum-resistant ovarian cancer patients. PD-1/PD-L1 inhibitors include Nivolumab, Pembrolizumab, Atezolizumab, Avelumab, Durvalumab, etc. In this paper, we reviewed the progress of PD-1/PD-L1 inhibitors for ovarian cancer especially the combination therapy.

Key words: Ovarian neoplasms, Immunotherapy, Programmed cell death 1 receptor, Antigens,CD274, Drug therapy,combination

MAO Ruo-nan, JIANG Wei. Progress in the Clinical Application of PD-1/PD-L1 Inhibitor in the Treatment of Ovarian Neoplasms[J]. Journal of International Obstetrics and Gynecology, 2021, 48(6): 605-609.

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