Research Progress of Asymptomatic Hypercholanaemia of Pregnancy

doi:10.12280/gjfckx.20210365

Abstract

Abstract:

Asymptomatic hypercholanaemia of pregnancy (AHP) refers to the increase of serum total bile acids during pregnancy, which exceeds the normal value by more than two times, without hepatobiliary diseases or intrahepatic cholestasis of pregnancy (ICP)-related symptoms. The incidence of AHP is higher than ICP, which may be related to hormone factors and genetic susceptibility. The composition of bile acid mass spectrometry is different from ICP, but the perinatal outcome is better than ICP. AHP with high total bile acid level is often difficult to differentiate from severe ICP in clinic, which leads to premature termination of pregnancy and even iatrogenic premature birth. Therefore, early detection and correct diagnosis of AHP, selection of appropriate treatment methods and appropriate timing of termination of pregnancy are the key to reduce iatrogenic intervention and premature delivery. In this paper, the etiology, pathogenesis, diagnosis and treatment of AHP are summarized.

Key words: Asymptomatic hypercholanaemia of pregnancy, Intrahepatic cholestasis of pregnancy, Cholestasis,intrahepatic, Pregnancy outcome, Therapy

LUO Ting, GUO Xue-dong, BAI Xiao-xia. Research Progress of Asymptomatic Hypercholanaemia of Pregnancy[J]. Journal of International Obstetrics and Gynecology, 2021, 48(5): 499-502.

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