Research Progress of Aromatase Inhibitors in the Treatment of Advanced or Recurrent Endometrial Cancer

doi:10.12280/gjfckx.20210580

Abstract

Abstract:

In recent years, the recurrence rate and mortality rate of endometrial cancer are on the rise, seriously threatening women′s life and health. Endocrine therapy plays a very important role in adjuvant therapy for postoperative prevention of recurrence and metastasis of endometrial cancer, as well as in the treatment of advanced or recurrent metastatic endometrial cancer. Aromatase inhibitors are common adjuvant endocrine heraputic drugs in clinical practice. They are highly selective and can reduce the stimulation of endometrial cancer cells by inhibiting estrogen synthesis, to inhibit the proliferation of tumor cells. This article reviews the clinical efficacy of aromatase inhibitors in endometrial cancer and discusses potential strategies to enhance the efficacy of aromatase inhibitors, such as combination of paclitaxel and carboplatin, combination of novel targeted therapies, and metformin.

Key words: Endometrial neoplasms, Neoplasm recurrence,local, Aromatase, Aromatase inhibitors, Drug therapy,combination

ZHANG Shao, KONG Xian-chao. Research Progress of Aromatase Inhibitors in the Treatment of Advanced or Recurrent Endometrial Cancer[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 1-4.

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