Application of Organoid in Cancer Research

doi:10.12280/gjfckx.20211126

Abstract

Abstract:

Nowadays, precise treatment and much more advanced tumor mechanism research have higher demand for tumor models. Tumor organoids, stem cell originated three-dimensional in vitro tumor models. Due to its simulation of in vivo tumor structure and characteristic, tumor organoids attract extensive attention. Compared with previous tumor models such as tumor cell lines and primary cells, a number of studies have shown that the tumor organoids are directly derived from patients, which can retain the somatic mutations and biological characteristics. Thanks to its short time expansion in vitro, tumor organoids in high-throughput drug screening can be used as a reference for patients′ precise treatment. Besides, tumor organoids can mimic the internal tumor microenvironment, retain the interaction between cells and extracellular matrix. At the same time, tumor organoids are available for gene editing. These characteristics of organoids make them suitable for promoting application as an in vitro tumor model in tumor precision therapy and basic research.

Key words: Organoids, Neoplasms, Drug screening assays,antitumor, Precision treatment, Gene editing

HUANG Hua, YAO Shu-zhong. Application of Organoid in Cancer Research[J]. Journal of International Obstetrics and Gynecology, 2022, 49(2): 176-180.

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