The Correlation between MicroRNAs and Endometrial Carcinoma

doi:10.12280/gjfckx.20211156

Abstract

Abstract:

Endometrial carcinoma, accounting for about 20%-30% of gynecological tumors, is a malignant tumor that seriously threatens women′s health. In recent years, research has shown that the incidence and mortality of the disease have increased gradually among urban women in China. In order to further clarify the pathogenesis of endometrial carcinoma, more and more scholars have studied the occurrence and development of endometrial carcinoma from the aspect of epigenetics. MicroRNAs (miRNAs) are small non-coding RNAs that widely participate in epigenetic regulation of cellular physiology and pathology. By reviewing the epigenetic effects of multiple miRNAs on tumor-related genes in endometrial carcinoma, we hope to further elucidate the possible molecular mechanisms of endometrial carcinoma pathogenesis and provide relevant basis for the exploration of new diagnostic and therapeutic targets.

Key words: Endometrial neoplasms, MicroRNAs, Cell proliferation, Apoptosis, Diagnosis, Therapy

MA Shou-ye, ZHAO Jing, LIU Hui-ling, WEI Zhen-hong. The Correlation between MicroRNAs and Endometrial Carcinoma[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 371-375.

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