The Mechanism of LncRNA in the Proliferation and Invasion of Ovarian Cancer

doi:10.12280/gjfckx.20211187

Abstract

Abstract:

Ovarian cancer is one of the most common gynecological malignancies with a high incidence, second only to cervical cancer and endometrial cancer. Most ovarian cancer patients are diagnosed in the middle or late stages. Studies have shown that long non-coding RNA (lncRNA) plays an important role in regulating the progression of ovarian cancer, especially the proliferation and invasion. The varieties of lncRNA are overexpressed or underexpressed in ovarian cancer tissues and cells, and the proliferation and invasion of ovarian cancer can be promoted or inhibited by regulating downstream signaling pathways, molecular sponge activating downstream target molecules and regulating protein expression. Knockout or silencing of lncRNAs with high expression can inhibit the proliferation and invasion of ovarian cancer, which may be a target for diagnosis and treatment of ovarian cancer. Some lncRNAs are also associated with ovarian cancer stage, lymph node metastasis, survival and other prognostic factors, which may be prognostic and outcome markers. The mechanism of lncRNA in proliferation and invasion of ovarian cancer was reviewed in order to provide evidence for diagnosis and targeted therapy of ovarian cancer.

Key words: Ovarian neoplasms, RNA, long non-coding, Cell proliferation, Neoplasm invasiveness, Defense mechanisms

ZHANG Ding-ding, LIANG Jing-qing, GU Nan-nan, LIU Su-fen. The Mechanism of LncRNA in the Proliferation and Invasion of Ovarian Cancer[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 376-381.

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