Abstract:

Long QT syndrome (LQTS) is a genetic heart disease caused by mutations in genes that lead to abnormalities in the structure or function of ion channels, and is characterized by prolonged QT interval and T-wave changes in the electrocardiogram (ECG), and it is prone to palpitation, synocope, arrhythmia, cardiac arrest and even sudden death. The most common genetic subtypes of LQTS patients are LQT1, LQT2, and LQT3. Different Genetic subtypes of LQTS have different mutation genes, triggers, and even ECG changes, so clarifying the genetic subtypes of patients can help clinical diagnosis, treatment and prevention of cardiac events. Effective prevention of cardiac events is one of the most important measures for patients with LQTS. During pregnancy and puerperium, women with LQTS will experience a series of physiological changes such as hormonal levels and hemodynamic changes, which may affect the risk of cardiac events associated with LQTS; their clinical management is also different from that of non-LQTS women, and it is necessary to review the research progress of its pathogenesis, diagnostic criteria, treatment options and perinatal management.

Key words: Pregnancy, Long QT syndrome, Peripartum period, Diagnosis, Therapy