Correlation between Sleep Quality and Metabolic Syndrome in Patients with Polycystic Ovary Syndrome

doi:10.12280/gjfckx.20220295

Abstract

Abstract:

Objective: To investigate the relationship between metabolic syndrome (MS) and sleep disorders in patients with polycystic ovary syndrome(PCOS), and to provide guidance for clinical prevention and treatment. Methods: 170 patients with PCOS (group A: PCOS with MS, group B: PCOS without MS) and 30 MS patients without PCOS (group C) were sorted as subjects for regression analysis. These patients are collected from the gynecology clinic of The First Affiliated Hospital of Heilongjiang University of Chinese Medicine from April to October 2021. The differences of clinical characteristics, sleep quality and the correlation between sleep status and metabolic syndrome markers were retrospectively analyzed. Results：There were 18 cases of sleep disorders in group A (45.00%), 44 cases in group B (33.84%) and 4 cases in group C (13.33%). There was significant difference in the distribution of sleep disorders among the three groups (P<0.05). Compared with group B, the SRSS score, body weight, BMI, SBP, DBP, WHR, FPG, FINS, HOMA-IR, TG, TC, LDL-c and ApoB in group A were higher, while the levels of LH, LH/FSH, SHBG and HDL-c in group A were lower than those in group B (P<0.05). Compared with group C, SRSS scores, LH, LH/FSH, T, DHEAS and AND in group A were higher, while the level of SHBG in group A was lower than that in group C (P<0.05). Early awakening and sleep instability were positively correlated with TG level in patients with PCOS (P<0.05). Conclusions：PCOS patients are easy to be complicated with sleep disorders. The sleep quality of MS and PCOS patients have mutual influence on sleep quality, and MS can aggravate sleep disorders in PCOS patients, so attention should be paid to sleep health in PCOS patients.

Key words: Polycystic ovary syndrome, Sleep disorders, Sleep apnea, obstructive, Metabolic syndrome, Dyslipidemias

KUANG Hong-ying, LI Shuang, CHENG Xian-zhuo, JIANG Xin-tong, HOU Li-hui. Correlation between Sleep Quality and Metabolic Syndrome in Patients with Polycystic Ovary Syndrome[J]. Journal of International Obstetrics and Gynecology, 2022, 49(4): 472-476.

Figures/Tables 6

References 20

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组别	n	无睡眠障碍	轻度睡眠障碍	中度睡眠障碍	重度睡眠障碍	H	P
A组	40	22（55.00）	11（27.50）	7（17.50）	0（0）	8.352	0.015
B组	130	86（66.16）	35（26.92）	9（6.92）	0（0）
C组	30	26（86.67）	4（13.33）	0（0）	0（0）

组别	n	无睡眠障碍	轻度睡眠障碍	中度睡眠障碍	重度睡眠障碍	H	P
A组	40	22（55.00）	11（27.50）	7（17.50）	0（0）	8.352	0.015
B组	130	86（66.16）	35（26.92）	9（6.92）	0（0）
C组	30	26（86.67）	4（13.33）	0（0）	0（0）

组别	n	体质量（kg）	BMI（kg/m²）	SBP（mmHg）	DBP（mmHg）	WHR
A组	40	80.00（70.00,91.75）	29.92（27.03,34.74）	132.00（118.00,138.75）	83.00（79.00,90.75）	0.87（0.84,0.92）
B组	130	64.00（55.00,72.12）^a	23.60（20.05,27.13）^a	117.00（111.00,122.00）^a	75.00（70.00,80.00）^a	0.81（0.77,0.87）^a
C组	30	78.00（60.00,85.00）^b	30.12（24.03,31.24）^b	136.00（130.00,147.00）^b	86.00（83.00,88.00）^b	0.85（0.84,0.89）
H		44.145	45.214	53.259	44.419	28.514
P		0.000	0.000	0.000	0.000	0.000

组别	n	体质量（kg）	BMI（kg/m²）	SBP（mmHg）	DBP（mmHg）	WHR
A组	40	80.00（70.00,91.75）	29.92（27.03,34.74）	132.00（118.00,138.75）	83.00（79.00,90.75）	0.87（0.84,0.92）
B组	130	64.00（55.00,72.12）^a	23.60（20.05,27.13）^a	117.00（111.00,122.00）^a	75.00（70.00,80.00）^a	0.81（0.77,0.87）^a
C组	30	78.00（60.00,85.00）^b	30.12（24.03,31.24）^b	136.00（130.00,147.00）^b	86.00（83.00,88.00）^b	0.85（0.84,0.89）
H		44.145	45.214	53.259	44.419	28.514
P		0.000	0.000	0.000	0.000	0.000

组别	n	LH （U/L）	FSH （U/L）	LH/FSH	PRL （ng/mL）	E₂ （pg/mL）	T （ng/dL）	DHEAS （μg/dL）	AND （nmol/L）	SHBG （nmol/L）
A组	40	6.92（4.26,10.16）	4.54（3.41,5.50）	1.51（1.09,2.22）	11.73（8.93,16.38）	38.50（27.00,61.37）	45.17（32.53,76.73）	274.22±119.91	8.11±3.69	27.40（18.65,41.47）
B组	130	8.97（5.50,12.62）^a	4.79（3.67,5.71）	1.95（1.35,2.69）^a	13.63（9.78,18.88）	42.43（30.00,66.75）	47.70（35.44,61.26）	289.71±102.84	7.78±2.72	36.80（22.80,65.35）^a
C组	30	4.11（2.11,6.44）^ab	4.91（2.78,6.55）	0.98（0.78,2.02）^ab	9.84（6.85,22.02）	36.00（24.00,49.00）	28.89（21.15,31.87）^ab	200.40±55.71^ab	4.56±1.91^ab	72.4（42.00,100.45）^ab
F或H		9.960	0.857	12.734	1.864	1.189	13.152	9.849	12.777	13.787
P		0.007	0.651	0.002	0.394	0.552	0.001	0.007	0.002	0.001