Research Progress of Lymphocytes Immunotherapy in Patients with Recurrent Spontaneous Abortion

doi:10.12280/gjfckx.20220746

Abstract

Abstract:

The incidence of recurrent spontaneous abortion (RSA) is increasing, which has become a serious problem for couples of reproductive age. The etiology of RSA is known to include chromosomal abnormalities, intrauterine diseases, endocrine abnormalities, infectious factors, etc., but the cause of 50% of RSA is still unknown, most of which are related to immune factors, and the specific mechanism is unknown. At present, immunotherapy such as lymphocytes immunotherapy has been applied to patients with negative blocking antibodies. Due to the lack of uniform standards for this treatment, some studies have widely different results, which make this treatment method not widely applied. Therefore, this article reviews the treatment methods to provide a basis for the clinical diagnosis and treatment, in order to improve the success rate of pregnancy in RSA patients.

Key words: Abortion, habitual, Antibodies, blocking, Immunotherapy, active, Lymphocytes, T-lymphocyte subsets, Killer cells, natural

WANG Rui-qi, DENG Zhi-min, DAI Fang-fang, CHENG Yan-xiang. Research Progress of Lymphocytes Immunotherapy in Patients with Recurrent Spontaneous Abortion[J]. Journal of International Obstetrics and Gynecology, 2023, 50(2): 138-141,160.

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