Giant Angiomyofibroblastoma of the Vulva Misdiagnosed as Liposarcoma on Magnetic Resonance Imaging: A Case Report

doi:10.12280/gjfckx.20230979

Abstract

Abstract:

Vulvar angiomyofibroblastoma (AMF) is a rare benign tumor that occurs in women of childbearing age, originating from the vulva or vagina. Liposarcoma typically occurs in the trunk and limbs of perimenopausal and postmenopausal women. We report a case where a large vulvar AMF was initially misdiagnosed as liposarcoma by magnetic resonance imaging (MRI). The patient who was admitted to the hospital because of the discovery of a vulvar mass for 3 years that had enlarged over one year, was diagnosed with liposarcoma via preoperative MRI. However, a preoperative biopsy revealed AMF. The patient underwent excision of vulvar mass and vulvovaginoplasty. Postoperative pathology confirmed the AMF diagnosis, with no recurrence observed during the postoperative follow up for 9 months. Clinicians should enhance the differential diagnosis of such condition and improve the diagnostic accuracy of AMF by combining preoperative histopathology and related imaging examinations, providing accurate clinical information for surgical guidance.

Key words: Angiomyoma, Neoplasms, muscle tissue, Vulva, Soft tissue neoplasms, Liposarcoma, Magnetic resonance imaging, Diagnostic errors

MA Hai-yan, ZHANG Yun-zhong, ZHENG Rong-fang, WANG Fu-rong, ZHANG Meng, GUO Yu-zhen. Giant Angiomyofibroblastoma of the Vulva Misdiagnosed as Liposarcoma on Magnetic Resonance Imaging: A Case Report[J]. Journal of International Obstetrics and Gynecology, 2024, 51(3): 263-266.

Figures/Tables 4

References 15

[1]	贾荣霞, 周旭, 石贽堃, 等. 外阴血管肌纤维母细胞瘤复发1例报告及文献复习[J]. 吉林大学学报(医学版), 2023, 49(1):193-197. doi: 10.13481/j.1671-587X.20230125.
[2]	Anggraeni TD, Nuranna L, Luthfiyanto M, et al. Rare case of huge vulvar angiomyofibroblastoma in a young female[J]. Gynecol Oncol Rep, 2021,36:100751. doi: 10.1016/j.gore.2021.100751.
[3]	Haddox CL, Riedel RF. Recent advances in the understanding and management of liposarcoma[J]. Fac Rev, 2021,10:1. doi: 10.12703/r/10-1.
[4]	Peng R, Li N, Lan T, et al. Liposarcoma in children and young adults: a clinicopathologic and molecular study of 23 cases in one of the largest institutions of China[J]. Virchows Arch, 2021, 479(3):537-549. doi: 10.1007/s00428-021-03076-8.
[5]	Fletcher CD, Tsang WY, Fisher C, et al. Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma[J]. Am J Surg Pathol, 1992, 16(4):373-382. doi: 10.1097/00000478-199204000-00006. pmid: 1314521
[6]	Kanda M, Sonoyama A, Hirano H, et al. Angiomyofibroblastoma of the vulva[J]. Eur J Gynaecol Oncol, 2014, 35(1):77-80. pmid: 24654468
[7]	Choi JH, Ro JY. The 2020 WHO Classification of Tumors of Soft Tissue: Selected Changes and New Entities[J]. Adv Anat Pathol, 2021, 28(1):44-58. doi: 10.1097/PAP.0000000000000284.
[8]	Johnson CN, Ha AS, Chen E, et al. Lipomatous Soft-tissue Tumors[J]. J Am Acad Orthop Surg, 2018, 26(22):779-788. doi: 10.5435/JAAOS-D-17-00045. pmid: 30192249
[9]	徐红, 杨太珠, 庞厚清, 等. 女性外阴血管肌纤维母细胞瘤超声表现1例[J]. 中国介入影像与治疗学, 2016, 13(12):719. doi: 10.13929/j.1672-8475.2016.12.002.
[10]	霍媛媛, 郝向云, 张桃桃, 等. 血管肌纤维母细胞瘤临床病理分析[J]. 现代肿瘤医学, 2021, 29(6):1009-1012. doi: 10.3969/j.issn.1672-4992.2021.06.022.
[11]	徐又先, 陈柏秀. 阴道侧壁血管肌纤维母细胞瘤1例[J]. 实用妇产科杂志, 2013, 29(11):877.
[12]	Gibbs J, Henderson-Jackson E, Bui MM. Bone and Soft Tissue Pathology: Diagnostic and Prognostic Implications[J]. Surg Clin North Am, 2016, 96(5):915-962. doi: 10.1016/j.suc.2016.06.003. pmid: 27542635
[13]	丁洪基, 高淑红, 孔翔, 等. 血管肌纤维母细胞瘤2例临床病理分析[J]. 临床与实验病理学杂志, 2016, 32(11):1276-1277,1280. doi: 10.13315/j.cnki.cjcep.2016.11.021.
[14]	化宏金, 司海鹏, 潘敏鸿, 等. 伴炎症性恶性纤维组织细胞瘤样形态学特征的去分化脂肪肉瘤7例临床病理特征[J]. 临床与实验病理学杂志, 2023, 39(10):1212-1216. doi: 10.13315/j.cnki.cjcep.2023.10.013.
[15]	Qiu P, Wang Z, Li Y, et al. Giant pelvic angiomyofibroblastoma: case report and literature review[J]. Diagn Pathol, 2014,9:106. doi: 10.1186/1746-1596-9-106.