Abstract:

The co-occurrence of partial hydatidiform mole (PHM) and severe preeclampsia in adolescents is extremely rare in clinical practice. This condition has an insidious onset and a complex clinical picture, with no clearly established diagnostic and therapeutic guidelines. A case of a 14-year-old patient admitted to Maoming Hospital of Guangzhou University of Chinese Medicine is reported. The patient was hospitalized with primary clinical manifestations of amenorrhea for over 10 weeks accompanied by abdominal pain, nausea and vomiting, and edema of bilateral lower limbs. The serum human chorionic gonadotropin-β (β-hCG) level was markedly elevated. Ultrasonography suggested features of PHM, and the patient also met the diagnostic criteria for severe preeclampsia. Treatment consisted of uterine evacuation combined with symptomatic management including antihypertensive and antispasmodic therapy. Postoperatively, the patient's symptoms gradually resolved, and her β-hCG levels progressively declined. The patient was lost to follow-up when her β-hCG level dropped to 28.725 U/L, and her long-term prognosis remains unknown. This case highlights the need for clinicians to strengthen their diagnostic and therapeutic awareness of such a unique disease entity. For such rare cases, it is crucial to obtain a timely history, achieve early and precise identification and diagnosis, manage the acute condition effectively, and emphasize follow-up management. This case provides practical reference for the clinical management of similar cases.

Key words: Adolescent, Gestational trophoblastic disease, Pre-eclampsia, Shock, hemorrhagic, Partial hydatidiform mole