Mechanisms of Oxidative Stress Impact on Protein Post-Translational Modifications in Preeclampsia

doi:10.12280/gjfckx.20260264

Abstract

Abstract:

Abnormal oxidative stress is a one of the key pathological features of the placenta in preeclampsia (PE) and affects trophoblast function and immune balance. Post-translational modifications (PTMs) refer to a series of covalent modifications occurring after protein translation. Numerous categories of PTMs have been identified in PE, and oxidative stress is extensively involved. Oxidative stress can regulate PTMs through direct protein damage, modulation of modifying enzyme activity, and alterations in metabolite levels, thereby coordinating PTMs in PE. Simultaneously, PTMs can influence cellular oxidative stress status. The two mutually regulate each other and jointly participate in placental oxidative stress regulation and placental function. However, the complexity of cellular oxidative metabolism in PE, the interactions among various PTMs, the mechanisms by which oxidative stress affects PTMs, and its regulatory role in PE pathogenesis remain unclear. This review summarizes the impact of oxidative stress on protein phosphorylation, ubiquitination, acetylation, lactylation, and other PTMs in PE by regulating the activity and expression levels of modifying enzymes. It also outlines the influence of glucose metabolism and lactate levels on placental oxidative stress status and function.

Key words: Oxidative stress, Pre-eclampsia, Protein processing, post-translational, Ubiquitination, Acetylation, Phosphorylation, Lactylation

WANG Jun, ZHU Jing-lei, PU Rui-yang, LI Shui-li, SUN Xiao-tong. Mechanisms of Oxidative Stress Impact on Protein Post-Translational Modifications in Preeclampsia[J]. Journal of International Obstetrics and Gynecology, 2026, 53(4): 447-451.

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