Abstract: Estrogen, as the most important sexual hormone of female, plays a significant role in women′s physiological functions or pathologic status changing procedure. Traditional theory holds that estrogen regulates transcription reaction or mediates signal transduction through the classical estrogen receptor ER α/β. GPR30 （also known as GPER） is a novel estrogen receptor, which has the ability to specially bind with estrogen or its derivatives, antagonists, and then leads to biological effect. Recently, in malignant tumors such as breast carcinoma, endometrial carcinoma or ovarian carcinoma, there were found over-expression of GPR30. Scholars studied the relationship between GPR30 and the occurrence and development of malignant tumors, in order to search for novel therapeutic targets in estrogen-related diseases, especially cancers.

Key words: Membranous estrogen receptor, GPR30, GPER, Malignant tumor