Abstract: Objective: To compare the diagnosis value of endometriosis（EMs） markers. Methods: Forty cases with EMs（EMs group）and thirty-four cases without EMs（control group） which were diagnosed through pathological sections after opening appendectomys were enrolled in this study. Levels of interkin-6 （IL-6）, tumor necrosis factor-alpha（TNF-α） and CA125 in serum and portioned fluid（PF） were detected by radioimmunoassay and immunoradiometric assay in them, we drew the ROC curves of EMs group, serum and PF and counted out their areas under the ROC curves. Results: In EMs group, the concentrations of three markers in serum were elevated significantly compared with those in the control group（P ＜0.05）. In EMs group, the concentrations of IL-6 and TNF-α　in PF were elevated significantly compared with those in the control group（P ＜0.05）, but no significant difference was found in CA125 of PF（P ＞0.05）. In EMs group, there were no positive correlation between the levels of three markers in serum and in PF（P ＞0.05）. In EMs group, the areas under the ROC curves of TNF-α in PF, TNF-α in serum, CA125 in serum, IL-6 in PF, IL-6 in serum, CA125 in PF were 0.902, 0.856, 0.790, 0.778, 0.700and 0.403 respectively. Conclusions: TNF-α in PF could hopefully be used as a diagnostic marker.

Key words: Endometriosis, Tumor necrosis factor-alpha, Interleukin-6, CA-125 Antigen, ROC curve