Abstract: Fetal hypoevolutism, abnormity, fetal death, miscarriage and other congenital anomalies are due to some internal reasons, e.g chromosome micro deletion, repeat, aneuploid and so on. Array comparative genomic hybridization （Array CGH） uses array to replace traditional metaphase chromosome as target crossing to samples and reference DNA labeled by different fluorescence, and the copy number alterations are detected by analysis of different fluorescence intensity. Array CGH is a powerful tool for cytogenetical study, and it has been used in prenatal diagnosis and congenital anomalies research for abnormal microarchitecture.

Key words: Array base comparative genomic hybridization, Congenital anomalies, Prenatal diagnosis