Abstract: Visfatin is a newly discovered one of the main visceral fat factors secreted by fat cells，with complicated structure and genetic polymorphism，which can regulate glucose and lipid metabolism，increasing insulin sensitivity，promoting vascular smooth muscle cell maturation， involving in inflammatory response and angiogenesis，and formation of atherosclerosis and vascular endothelial cell damage and dysfunction. Pre-eclampsia is a pathology of unknown cause in pregnancy，seriously endanger the life of mother and child，vascular endothelial cell injury and dysfunction may lead to the ultimate incidence of pre-eclampsia and the emergence of the root causes of the clinical manifestations. People speculated that visfatin may be involved in a variety of ways to the pathogenesis of pre-eclampsia，as one of the focuses of current research.

Key words: Nicotinamide phosphoribosyltransferase, Pre-eclampsia, Insulin resistance, Polymorphism, single nucleotide, Adipokines