Abstract: Intrahepatic cholestasis of pregnancy（ICP）is a liver function unique to pregnancy，which usually manifests during late pregnancy. It is one of the two acquired cholestasis.The occurrence of ICP carries a high risk for the baby because of premature spontaneous delivery，meconium passage and sudden fetal death. However，the cause of ICP is unknown. There is increasing evidence that ICP might connect with hormone，genetic variability，immune and environmental factor. For the past few years，the investigation on relationship between pathogenesis and gene mutation has become a hot spot. It has become evidence that ICP is mainly correlate with gene mutation，including multidrug resistance protein 3（MDR3，ABCB4）gene，bile salt export pump（BSEP，ABCB11）and the familial cholestasis type 1（FIC1，ATP8B1）gene. Genetics may also play an important role in development of ICP.

Key words: Genes, Mutation, Pregnancy, Cholestasis, intrahepatic