Journal of International Obstetrics and Gynecology ›› 2011, Vol. 38 ›› Issue (5): 428-431.

• 综述 • Previous Articles     Next Articles

Research Advancement in Tumor Suppressor Genes of Endometrial Carcinoma

ZHANG Jia,WANG Yong-hong   

  1. Department of Obstetrics and Gynecology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15
  • Contact: WANG Yong-hong

Abstract: Endometrial cancer(EC)is one of the most common genital cancers in women worldwide,and the incidence increases year by year. With the development of immunology and molecular biology,there are more and more investigations in molecular mechanism of endometrial cancer,such as oncogenes,tumor suppressor genes,DNA mismatch repair genes,estrogen metabolic enzyme genes,steroid hormone receptor gene,cell cycle regulatory proteins,etc. In this study,the tumor suppressor genes of endometrial carcinoma were summarized,which might play an important role in tumor formation,development,treatment and prognosis.

Key words: Endometrial neoplasms, Genes, tumor suppressor, PTEN phosphohydrolase, Tumor suppressor protein p53, Genes, Cyclin-dependent kinase inhibitor p27, Human runt-related transcription factor 3, Checkpoint with FHA and ring finger genes