Abstract: Gestational trophoblastic disease（GTD）is a group of heterogeneity diseases with different clinical，morphological and biological characteristics. Its common feature lies in trophoblastic abnormality. Although hydatidiform mole is a benign disease of the gestational trophoblastic diseases，it has the potential risk of malignant transformation. At present we are mainly based on closely monitoring the serum human chorionic gonadotropin（hCG）attenuation curve to check the underlying malignant lesion. In recent years，with the development of laboratory diagnostic techniques and detection equipments，there are more and more alterations in genetics，biochemical indicators and sonography reported to predict the malignant transformation of hydatidiform mole，trying to obtain precise and early diagnosis of this situation. This article is aimed to briefly introduce these significant prognostic indicators.

Key words: Gestational trophoblastic neoplasms, Chorionic gonadotropin, Oncogenes, STAT3 transcription factor, Diagnostic imaging, Forecasting