Abstract: Wnt signal pathway is a key way to regulate cell development and growth. In normal circumstances，it plays a significance role on the embryonic development and tissue formation. Its abnormal activation is involved in the pathogenesis of many human tumors. The present study show that a variety of molecules of Wnt signal pathway are closely related to the occurrence and development of uterine leiomyoma，which play roles by influencing apoptosis， angiogenesis，etc，and have interaction with many kinds of growth factors. However，some Wnt molecules expressed in the uterine leiomyoma is still disputed. This article is a brief review about recent advances in Wnt signal pathway and its relation to uterine leiomyoma.

Key words: Proteins, Signal transduction, Uterine neoplasms, Myoma