Table of Content

15 April 2012, Volume 39 Issue 2
Previous Issue    Next Issue
---
述评
综述
论著


For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

述评

Select

Recognition on Diagnosis and Treatment of Uterine Myomas SHI Yi-fu;LI Juan-qing 2012, 39 (2):  109-111.  Abstract ( 2260 )   PDF (278KB) ( 4938 )   Uterine myomas are one of the most common tumors of the female reproductive tract and a major public health problem. However，there are still a lot of problems to be completely understood. Although uterine myoma is very common in clinical，the data of incidence and morbidity used is collected ten years ago. Thus，it is necessary to take epidemiological investigation widely. The treatment methods and theory of uterine myoma have been changed gradually. Uterine myoma couldn't be treated by the same therapy instead of many methods from laparotomy to microlaparoscopy. It is important to pay attention to the clinical and special problems in uterine myoma such as infertility，family planning，hormone replacement therapy，sex and sexual function，obstetrics，pathology and oncology reproduction. Gynecologic oncologists shouldn't study malignant tumors merely. They should attach great importance to benign tumors at the same time. Related Articles | Metrics

综述

Select

Effects of Estrogen on Cognitive Function in Women XU Jie;REN Mu-lan 2012, 39 (2):  112-114.  Abstract ( 1729 )   PDF (216KB) ( 4746 )   Estrogen is one of the gonadal hormones that has multiple beneficial actions in central nervous system and involves in learning and memory. Therefore，it has been hypothesized that the change of estrogen levels in women following menopause is associated with cognitive-related diseases. Now，contradictory results in the studies of menopausal or postmenopausal women have prompted speculation that a critical period exists for hormone treatment to protect against cognitive decline in older women. Consistent with this hypothesis， studies in both women and rodents discussed the effects of estrogen on cognitive function and whether the initiation of hormone treatment is an important factor of preventing or exacerbating cognitive impairment by analyzing the change of brain function when estrogen drops and exogenous estrogen is supplied，which is greatly significant for prevention and treatment of cognitive decline in women following menopause. Related Articles | Metrics

Select

Discuss the Detecting Items of Hyperandrogenism and the Measurement Methods of Androgen HUANG Mei-feng;ZHAO Xiao-miao;YANG Dong-zi 2012, 39 (2):  115-118.  Abstract ( 1820 )   PDF (246KB) ( 4914 )   Hyperandrogenism is one of the common features of polycystic ovarian syndrome（PCOS）. It is very important to discover and treat this disease early because of its high prevalent rate in the reproductive age women. Nowadays，the hospitals in all over the world still use ELISA to detect the Free testosterone and chemiluminescence to detect the Total testosterone. There are many studies about the assay methods and projects for androgen and most studies demonstrated that these assay methods for testosterone have been fraught with accuracy problems；they are not sensitive for the females because of their low serum androgen concentration. Meanwhile，the androgen determination projects still has not reached the consistent mutual recognition. It prompts there is possiblily a majority patients accompanied by hyperandrogenism have not been diagnosed. Radioimmunoassay analysis and the mass spectrometrybased methods are considered to be the highly effective，but it is very difficult to use in the clinic and diagnose the disease because of many reasons. Related Articles | Metrics

Select

The Impact of Androgen Excess on the Initiation and Development of Polycystic Ovary Syndrome DING Tao;ZHENG Yan-hua;XIE Jun;MA Hong-xia;WU Xiao-ke 2012, 39 (2):  119-124.  Abstract ( 1569 )   PDF (273KB) ( 4862 )   Although the aetiology of polycystic ovary syndrome（PCOS） is unknown and the search for causative genes is elusive，androgen excess is generally thought of an important triggers of PCOS.We known that excess androgens is the root cause of PCOS starting from the female fetus，producing the characteristic signs and symptoms which are then exacerbated by the excess ovarian androgen production from multiple small follicle，anovulation and insulin resistance in the reproductive life-span，thus setting up a vicious perpetual circle of excess androgen.The paper is biased in support of the hypothesis that androgen excess is the“root of all evil”in PCOS. Related Articles | Metrics

Select

The Gene Polymorphism Research Review of Polycystic Ovary Syndrome ZHANG Xin-lin;ZHANG Cheng-wei;WANG Yong 2012, 39 (2):  125-128.  Abstract ( 1575 )   PDF (265KB) ( 4871 )   Polycystic ovary syndrome（PCOS）is a common disease in women of child-bearing age，characterized by the presence of hyperandrogenism，insulin resistance，and hyperinsulinism. PCOS is one of the most controversial entities in gynecological endocrinology， and it has been proven to be a familial inheritance. However，up to date， genes that may be involved in the etiology of PCOS have not been fully investigated，and no gene has been universally accepted as the fundamental pathogenic gene. Because of the heterogeneity of the syndrome， research becomes more difficult. Till now the genes investigated are mainly related to the regulation of androgen biosynthesis and function，insulin resistance，and chronic inflammation. Related Articles | Metrics

Select

Advances in the Hereditary Susceptibility of Polycystic Ovary Syndrome ZHANG Rui;SHI Hui-rong 2012, 39 (2):  129-132.  Abstract ( 1548 )   PDF (307KB) ( 4834 )   Polycystic ovary syndrome（PCOS）is one of the endocrine disorders with reproductive dysfunction and glucose metabolism disorders，which is one of the most common reason of infertility of women in the reproductive age. So far，its pathogenesis has not been clear. It is now thought that the complicated clinical manifestations and biochemical characteristics of PCOS are the concomitant result of many genes and environmental factor. Its biochemical characteristics suggests that the pathogenesis is related to abnormal interaction of several genes，including genes involving the synthesize and action of steroid hormone，genes involving the secretion，and action of insulin，genes involving the effect and regulation of gonad stimulating hormone，and inflammatory factor genes．So the study on hereditary susceptibility of PCOS is helpful to further revealing its pathogenesis. Related Articles | Metrics

Select

Progress on Adiponectin and Polycystic Ovarian Syndrome TAO Jun;FAN Jian-xia 2012, 39 (2):  133-136.  Abstract ( 1512 )   PDF (220KB) ( 4773 )   Polycystic ovary syndrome（PCOS）is a complicated，multi-system endocrine and metabolic disease. Its etiology is impaired by multiple genetics and environmental factors. Obesity is significantly higher in PCOS than average women. As a result，PCOS patients have obvious adipose tissue dysfunction and metabolic syndrome. With the recent in-depth study on adipocytokines secreted from adipose tissue，it was discovered that adiponectin and its receptors were closely related to insulin resistance and long-term cardiovascular disease in PCOS. High molecular weight adiponectin may be better to reflect the actual role of insulin resistance in PCOS. Polymorphism of adiponectin gene may be the susceptibility gene in PCOS. Thus，adiponectin has become the focus of PCOS research. Related Articles | Metrics

Select

Progress About Wnt Signal Pathway and Uterine Leiomyoma SHI Yang;ZHAO Li;CAO Yang;ZHOU Jie-yun;YANG Ying;ZHANG Ting-ting 2012, 39 (2):  137-140.  Abstract ( 1531 )   PDF (265KB) ( 4811 )   Wnt signal pathway is a key way to regulate cell development and growth. In normal circumstances，it plays a significance role on the embryonic development and tissue formation. Its abnormal activation is involved in the pathogenesis of many human tumors. The present study show that a variety of molecules of Wnt signal pathway are closely related to the occurrence and development of uterine leiomyoma，which play roles by influencing apoptosis， angiogenesis，etc，and have interaction with many kinds of growth factors. However，some Wnt molecules expressed in the uterine leiomyoma is still disputed. This article is a brief review about recent advances in Wnt signal pathway and its relation to uterine leiomyoma. Related Articles | Metrics

Select

Endometrial Polyps：the True Cancer Precursor？ LI Wen-xue;WANG Xiao-lei 2012, 39 (2):  141-144.  Abstract ( 1547 )   PDF (233KB) ( 4787 )   Endometrial polyps （EPs） are a common endometrial lesions. Although etiology and pathogenesis of Eps are unclear until now. At present，they are considered as estrogen-dependent lesions，and some may transform into endometrial cancer. The detectable rate of Eps increases with application of hysteroscopy technology.Menopause and abnormal uterine bleeding increase the risk of endometrial polyp malignancy.At present，The primary management of Eps is surgery.But Eps are easily recur after treatment.Choosing appropriate operative treatment and preventive measure according to the high-risk factors of recurrence and malignancy.In this article the anthor reviewed EPs and its manlignancy，treatment and prevention. Related Articles | Metrics

Select

The Progress of Relationship Between Glucose Metabolic Disorder and Endometrial Carcinoma HU Sai-nan;FENG You-ji 2012, 39 (2):  145-147.  Abstract ( 1550 )   PDF (233KB) ( 4955 )   Glucose metabolic disorder can cause Impaired fasting glucose（IFG） and Impaired glucose tolerance（IGT），even Diabetes Mellitus，Obesity and Hypertension.These diseases are caused by glucose，lipid and protein metabolic disorder，which are closely related with many kinds of carcinoma，such as rectal cancer，breast cancer and of couse endometrial cancer. Refering to the essential aspect ，insulin resistance maybe the most important reason.In the future，we can increase the curative ratio of endometrial cancer through improving the glucose metabolic disturbance，controling body weight and treating Diabetes，all of which may turn into efficient measures of the prevention and treatment of Endometrial carcinoma. Related Articles | Metrics

Select

Research Progress in Tumor Markers for the Early Diagnosis of Ovarian Cancer ZHANG Yan;LI Ya-li 2012, 39 (2):  148-151.  Abstract ( 1428 )   PDF (240KB) ( 4851 )   Ovarian cancer is one of the common gynecologic malignancies，because there are no obvious symptoms in early stage and lack of effective early diagnostic method，mortality is the highest in gynecological cancers。Genomics，proteomics，immunohistochemical technology and other research methods have become research hotspot in early diagnosis of ovarian cancer，in order to discover higher sensitive and specific tumor markers。This paper reviews current novel tumor markers in relation to ovarian cancer。 Related Articles | Metrics

Select

Targeted Therapies Advances in Ovarian Cancer YU Yi;XU Cong-jian 2012, 39 (2):  152-157.  Abstract ( 1679 )   PDF (345KB) ( 4783 )   Ovarian cancer is the leading cause of death from gynecological cancer. Although some advances in surgical and chemotherapeutic strategies have been made， there still remains a significant risk for recurrence and resistance to therapy. Targeted therapy become a effective method against ovarian cancer， which could improve the ability to kill cancer cells and to reduce the damage to normal tissues. Targeted therapy has gradually applied to clinical treatment and shown an advantage to tranditional ones. This paper review targeted therapies in ovarian cancer in form of molecular targeted and gene targeted， in order to know about the current situation and the prospective research of the treatment in ovarian cancer. Related Articles | Metrics

Select

MicroRNA in Ovarian Cancer Drug Resistance and Prognosis ZHUANG Yu-yu;WAN Xiao-ping 2012, 39 (2):  158-162.  Abstract ( 1493 )   PDF (410KB) ( 4788 )   Resistance to chemotherapy is a major cause that leads to poor prognosis in advanced ovarian cancer. Identification of chemosensitivity biomarkers for ovarian cancer has become a hotspot.MicroRNAs are small non-coding RNA molecules that can negatively regulate gene expression at the posttranscriptional level. A rapidly growing number of recent studies show that some aberrantly expressed miRNAs in ovarian cancer could target genes related to drug sensitivity，resulting in the altered sensitivity of cancer cells to anti-cancer drugs；the specific targeting of miRNAs could open new avenues for cancer treatment through overcoming drug resistance. These results suggest that miRNAs may be a potentially useful tool for prognostic stratification and individualized treatment.This review focused on the research progresses of miRNAs in ovarian cancer drug resistance and prognosis. Related Articles | Metrics

Select

Progress of Fertility Preservation Treatments in Patients with Borderline Ovarian Tumors GUI Yun;ZHAO Wei-dong 2012, 39 (2):  163-165.  Abstract ( 1444 )   PDF (223KB) ( 4711 )   Facing to young patients with borderline ovarian tumors（BOTs），fertility preservation surgery is the best option to preserve fertility. Fertility preservation surgery is acceptable not only for patients with early-stage BOTs but also for someone with noninvasive extra-ovarian implants which can be resected completely. The pregnancy outcomes after surgery is recognized and most of the pregnancies have been achieved spontaneously. The complications followed by pregnancy are few，and pregnancy seems to have little impact on disease progression. Superovulation drugs are tolerated in early-stage BOTs patients who experience infertility after surgery，but it should be caution when using these drugs in advanced-stage BOTs patients after surgery. If the normal ovarian portion cannot be preserved due to massive bilateral ovarian involvement and only the uterus can be preserved，the surgery can not be choosed. But there are several alternative options for fertility preservation，such as embryo freezing，oocyte，ovarian tissue freezing; and using donor ooccytes. Related Articles | Metrics

Select

Regulatory Effects of CPI-17 on Smooth Muscle and Its Mechanism ZHOU Zhi-mei;YAN Jian-ying 2012, 39 (2):  166-169.  Abstract ( 1556 )   PDF (262KB) ( 4879 )   The coordinated regulation of contraction is a key property of smooth muscle，Proper function contributes to general health，but dysfunction is associated with morbidity and mortality.CPI-17（protein kinase C-potentiated phosphatase inhibitor of 17 ku）is a phosphorylation-dependent myosin phosphatase inhibitory protein，increases the phosphorylation level of 20 ku myosin light chain and enhances smooth muscle contraction.Multiple kinases and phosphateses are involved in regulating CPI-17 phosphorylation.Recent evidences show that up-and down-regulation of CPI-17 occurs under pathophysiological conditions，resulting in abnormal contraction of various smooth muscle，such as myometrium，blood vessel，trachea，gastrointestinal tract.Further studies on regulatory mechanism of CPI-17 on smooth muscle will be useful to elucidate the pathogenesis of many diseases/disorders associated with smooth muscle dysfunction and provide a new idea for the clinical treatment. Related Articles | Metrics

Select

The Effect of Autoimmune Thyroid Diseases on Pregnancy Outcomes and Female Fertility REN Xiu-lian;SU Heng 2012, 39 (2):  170-174.  Abstract ( 1542 )   PDF (254KB) ( 4985 )   Thyroid autoimmune diseases are quite prevalent in women of reproductive age， including hyperthyroidism，hypothyroidism during pregnancy and postpartum thyroiditis. TPOAb，TGAb and TRAb are the important markers of autoimmune thyroid dysfunction. The presence of thyroid dysfunction is associated with some adverse effects on fetal and maternal outcomes. Euthyroid women with positive anti-thyroid antibodies in pregnancy are at increased risks for thyroid insufficiency during pregnancy and postpartum thyroiditis，and should be monitored with TSH and TT4. In addition，the thyroid autoimmunity may be related with infertility and abortion. Early screening，diagnosis and proper treatment may effectively reduce the occurrence of adverse pregnancy outcomes in high risk individuals. Related Articles | Metrics

Select

TLR4，NF-κB and Early Spontaneous Abortion LI Sha;ZHAO Xian-lan 2012, 39 (2):  175-178.  Abstract ( 1419 )   PDF (294KB) ( 4786 )   Early spontaneous abortion is one of the common pathologic pregnancy in obstetrics.The etiology is complicated，and pathogenesis is not yet clear. Reproductive immunology thinks spontaneous abortion is immune imbalance in maternal-fetal interface，maternal tissues engender immune rejection to fetal tissues.TLR4 is an important kind of pattern recognition receptors in the innate immune system， the activation of TLR4 signal transduction pathway makes some pathological changes in maternal-fetal interface， breaking original immune balance， causing miscarriage. Thus，TLR4-NF-κB pathway may play an important role in the development of early spontaneous abortion. The relationship between TLR4-NF-κB pathway and early spontaneous abortion is reviewed in this paper. Related Articles | Metrics

Select

Diagnosis and Treatment Progress of Pregnancy with Cervical Cancer HAN Xiao-qing;ZHAO Xian-lan 2012, 39 (2):  179-182.  Abstract ( 1395 )   PDF (275KB) ( 4891 )   The diagnosis and treatment of the gynecologic cancers in pregnant woman presents a significant challenge for the obstetrician and gynaecologist because of many reasons. The treatment options for pregnant patients with the gynecologic cancers depend on gestational age，clinical stage，neoplasms by histologic type，the patient's wishes with fetus and bearing requirement. Unfortunately，the clinical experience for how to deal with such special clinical problem is relatively limited，and now there is no universally accepted guideline for the treatment. This is a literature review of diagnostic and treatment strategies for combined with pregnancy cervical carcinoma for example. Related Articles | Metrics

Select

Progress on Etiology Research of Congenital Heart Disease SHI Miao;HONG Xin-ru;SUN Qing-hua 2012, 39 (2):  183-186.  Abstract ( 1550 )   PDF (306KB) ( 5401 )   Congenital heart disease（CHD），one of the most common birth defects，which brings tremendous burden on society and families，has become a primary disease affecting the life and health of infants and young children .In recent years，the research on etiology of CHD has made a considerable progress. This review summarizes the currently available literature on potential fetal exposures that might enhance the risk for cardiovascular defects．Information is summarized for genetic factors，physical and chemical factors（industrial and agricultural pollution，X-ray radiation，air pollution，smoking，alcohol abuse，etc.），infection during pregnancy，medication during pregnancy，maternal mental stress and maternal diseases．CHD generally results from the comprehensive effects of multitude risk factors rather than single one or their simple combination．Preventive intervention targeting risk factors should be suggested，which would help reduce the occurrence of CHD． Related Articles | Metrics

论著

Select

Human Cord Blood Mononuclear Cell Transplantation in the Treatment of Radioactive Experimental Study of Premature Ovarian Failure in Nude Mice DANG Jian-hong;JIN Zhi-jun;GE Jun-hui;HU Dian;PENG Fei 2012, 39 (2):  187-190.  Abstract ( 1548 )   PDF (1280KB) ( 4768 )   Objective：This study was aimed to explore the feasibility and effects of human cord blood cell transplantation for the treatment of premature ovarian failure（POF） in nude mices. Methods：Thirty female nude mouse were randomly divided into three groups，Normal control group（n=35） and premature ovarian failure（POF plus vehicle，n=35）；POF plus cell transplantation（HCMNCs were implanted into the bilateral ovarian，n=35）. Cobalt-60 irradiation was used to establish POF models. HCMNCs were isolated by ficoll density gradient centrifugation，and labled by BrdU. Four weeks after transplantation，the nude mice were sacrificed for determination of serum E2，FSH，LH，histological and immunochemical examination of the bilateral ovaries. Results：The transplanted HCMNCs survived in transplantation group and participated the repair process in ovaries. The serums of E2， FSH，LH of the transplantation group were compared with POF control group. E2 significantly increased（P＜0.05）， FSH decreased significantly（P＜0.05），LH decreased significantly（P＜0.05）. And also found the number of follicles recovered. Conclusions：HCMNCs can be successfully transplanted into nude mice ovaries，and can improve the recovery of ovarian function. Related Articles | Metrics

Select

Analysis on 2 066 Cases of Imbalance in Female Vaginal Micro-ecological Environment XIAO Cai-yan;ZHANG Hong-wen;WANG Xin;LI Han;ZHOU Ying 2012, 39 (2):  191-193.  Abstract ( 1453 )   PDF (222KB) ( 4987 )   Objective：To investigate the gynecological clinic detection rate ，proportion and age distribution of vaginal microflora imbalance. Methods：Gram staining gynecological clinic patients with clinical symptoms of vaginal secretions， detection of vaginal pH. Results：Vaginal microbial disorder detection rate was 51.33%，vulvovaginal candidiasis accounted for 28.99%， bacterial vaginosis accounting for 8.57%，trichomoniasis vaginosis was 2.03%，mixed vaginitis was 0.48%，undefined vaginal microbial imbalance was 59.92%. Vaginal microbial disorders in patients composition of each age group：＜20 years old was 2.4%，21-30 age group was 32.7%，31-40 age group was 38.2%， 41-50 age group was 21.7%，＞50 years old group was 5.0%，all kinds of vaginal micro-ecological imbalance， the median age in addition to mixed vaginitis was in 21-30 years old， the other are in the 31-40 years of age. Conclusions：Vulvovaginal candidiasis were higher than bacterial vaginosis，trichomonas vaginitis and mixed vaginitis. Vulvovaginal candidiasis，bacterial vaginosis，trichomonas vaginitis and mixed vaginitis were predilection in reproductive age females. In addition to inflammation of the vagina， there are most of the vaginal microbial disorders need to define. Related Articles | Metrics

Select

The Clinlical Value of CA19-9 Verses CA125 in Diagnosis of Endometriosis ZHANG Qing;LUO Ruo-yu;XU Yi;LI Hua;HUANG Li 2012, 39 (2):  194-195.  Abstract ( 1621 )   PDF (229KB) ( 4770 )   Objective：To investigate the diagnostic values of CA19-9 and CA125 in the serum for endometriosis. Methods：CA19-9 and CA125 serum levels were determined with RIA in 55 patients with endometriosis and 25 control healthy women. Results：the mean serum levels and positive rate of CA19-9 and CA125 for endometriosis and controls are 27.81 U/mL、43.6%，11.78 U/mL，0 and 24.2 U/mL、36.3%， 9.02 U/mL，4.0%，respectively. There is significant difference between the measure result and positive rate of CA19-9 and CA125 for endometriosis group and control（P＜0.05）. The mean serum levels of CA19-9 and CA125 in patients at stages Ⅲ～Ⅳ and Ⅰ～Ⅱ，according to the Revised American Fertility Society（R-AFS） classification，are 42.38 U/mL、57.9%，17.36 U/mL、11.8% and 34.75 U/mL、50.0%，15.3 U/mL、5.9%. The difference of the mean serum levels and positive rate between the groups is significant（P＜0.05）. The sensitivity，specificity and accuracy of CA19-9 and CA125 serum levels in diagnosis of endometriosis are 43.6%，100% and 61.25%；36.3%，96.0% and 55.0%，respectively. Conclusions：Measure the levels of CA19-9 and CA125 in serum can raise the sensitivity of diagnosis for endometriosis. The predictive values of CA19-9 and CA125 seem high only to predict severe（stages Ⅲ and Ⅳ） disease. Related Articles | Metrics

Select

The Expression of Matrix Metalloproteinase-3 and Tissue Inhibitor of Metalloproteinases-3 in Placenta of Pregnant Women with Preeclampsia CHENG Xin;WANG Yong-hong 2012, 39 (2):  196-198.  Abstract ( 1344 )   PDF (1389KB) ( 4753 )   Objective：To detect the expression of matrix metalloproteinases-3（MMP-3）and tissue inhibitor of metalloproteinases-3（TIMP-3）in placenta of the patients with preeclampsia，and to investigate the role of MMP-3 and TIMP-3 in the pathogenesis of preeclampsia. Methods：The levels of MMP-3 and TIMP-3 in placental tissues were measured from 34 patients with preeclampsia（study group）and 32 normal pregnant women（control group）by immunohistochemistry. HE staining was used in order to count the number of the vessles. Results：MMP-3 and TIMP-3 were expressed in the decidual cell and the villous trophoblast in both group. Whether in decidual cell or in villi trophoblast cell，MMP-3 in preeclampsia group was significantly lower than that in the control group，but TIMP-3 was obviously higher in preeclampsia group. The count of vessels reduced in preeclampsia group. Conclusions：The differences of MMP-3 and TIMP-3 in placental tissues between preeclampsia group and control group suggest that those changes may associate with the pathogenesis of preeclampsia. Related Articles | Metrics

Select

Effect of Cinobufagin on the Invasive Growth of Endometrial Carcinoma HHUA Cells WANG Shao-guang;JIANG Xue-qiang 2012, 39 (2):  199-201.  Abstract ( 1493 )   PDF (270KB) ( 4820 )   Objective：To investigate the effect of cinobufagin on the invasive growth of the endometrial carcinoma HHUA cells cultured in vitro. Methods：Endometrial carcinoma HHUA cells were cultured in vitro；after the action of cinobufagin with different concentration，MTT method was used to detect the proliferation of HHUA cells，the cellular apoptosis was tested by flow cytometry，the expression of CD44s was measured by RT-PCR，the ability of invasion was compared with transwell chamber model. Results：Endometrial carcinoma HHUA cells expressed CD44s mRNA of （1.31±0.25），number of invasive cell was 60.50±2.52；0.25 g/L cinobufagin didn't affect CD44s and invasive cell（P＞0.05）； after the action of 2.5 g/L cinobufagin，the expression of CD44s was 1.02±0.23， number of invasive cell was（30.50±3.95），these deta were different from the control group of endometrial carcinoma HHUA cells significantly（P＜0.05）；after the action of 25 g/L cinobufagin，the expression of CD44s was 0.97±0.39，number of invasive cell was 22.50±4.22，these data were different from the control group of endometrial carcinoma HHUA cells significantly（P＜0.05）；the action of 25 g/L cinobufagin was similar to that of 0.25 g/L cinobufagin（P＞0.05）. Conclusions：2.5 g/L cinobufagin inhibit the expression of CD44s mRNA and inhibit the invasive growth of the endometrial carcinoma HHUA cells. Related Articles | Metrics

Select

Prevention of Pelvic Lymphocyst After Pelvic Limphonodes Dissection HAN Li-ping;HOU Na;GAO Mei;SHI Hui-rong;LI Liu-xia;ZHAO Li-juan 2012, 39 (2):  202-205.  Abstract ( 1427 )   PDF (329KB) ( 4973 )   Objective：To Investigate the value of Ultrasonic scalpel and BiCamp in abdominal pelvic lymphadenectomy. Methods：Among 158 cases who received abdominal pelvic lymphadenectomy in our hospital from Jan 2009 to Oct 2010， 58 cases were performed using ultrasonic scalpel or BiCamp and the other 100 cases without using ultrasonic scalpel or BiCamp. The operative time， interoperative blood loss， pelvic drainage， postoperative urination recovery time and hospital stay were compared between two groups. Results：With Ultrasonic scalpel and BiCamp， the operative time was shorter， the interoperative blood loss was less and the incidence of postoperative lymphocele was low. The difference between the two groups was statistically signifcant（P＜0.05）. Conclusions：It will reduce the operative time， the interoperative blood loss and the incidence of postoperative lymphocele by using ultrasonic scalpel or BiCamp in abdominal pelvic lymphadenectomy. BiCamp and ultrasonic scalpel should be recommanded. Related Articles | Metrics

Select

35 Cases of Hysteroscopic Transcervical Resection Remedy Refractory Cornual Pregnancy WU Yi-lin;ZHANG Hong-wen;CHEN Pu-xiang;WANG Ying-xia;LIU Feng-ying;FU Chun;DING Hui;NIE Mei-fang 2012, 39 (2):  206-207.  Abstract ( 1545 )   PDF (239KB) ( 4970 )   Objective：Summarize the clinical experience of hysteroscopic transcervical resection remedy on refractory cornual pregnancy. Methods：A total of 35 cases of refractory cornual pregnancy（After more than 2 times curettage or even by Ultrasound，hysteroscopic fixed curettage failed）were treated with hysteroscopic transcervical resection from January 2007 to January 2011 were analysed retrospectively. Results：34 cases were operated once successfully，only one case was operated again because the residue of embryo adhesion and superficial imbedding the uterine wall，the operation time（23.0±8.3） min，and the blood loss（30.5±6.2） mL，the weight of placenta varied（12.0±6.5） g， the volume of liquid of expanding uterus（3 808.3±529.5） mL. Conclusions：Hysteroscopic transcervical resection is safe and effective in treatment of cornual pregnancy residue of embryo and have good clinical value，worthy of promotion. Related Articles | Metrics

Select

Prenatal Diagnosis of Thalassemia in 2 171 Cases DU Li;YIN Ai-hua;ZHANG Yan;LIANG Ju-qing;ZHOU Wei-ning;WANG An-shi;LAN Fei-fei;LI Hai-xia 2012, 39 (2):  208-210.  Abstract ( 1931 )   PDF (240KB) ( 4796 )   Objective：To make a retrospective analysis about 1 506 prenatal diagnosis cases of α-thalassemia and 665 cases of β-thalassemia in the prenatal diagnosis center of women and children hospital of Guangdong Province. Methods：Gap-PCR and polymerase chain reaction-reverse dot blot（PCR-RDB）assay. DNA sequencing was used in the case when unusual mutation was identified in at least one parent. Results：262 cases of Bart′s fetuses and 72 cases of Hb H were detected in 1 506 cases of α-thalassemia prenatal diagnosis. Meanwhile，174 fetuses with complex mutation were final diagnosed from 665 cases of β-thalassemia prenatal diagnosis. Conclusions：Prenatal diagnosis of thalassemia can effectively reduce the birth of Bart′s fetuses and seriously β-thalassemia，and it has the vital significance for eugenic birth and decrease of the perinatal complication. Related Articles | Metrics