Abstract: Resistance to chemotherapy is a major cause that leads to poor prognosis in advanced ovarian cancer. Identification of chemosensitivity biomarkers for ovarian cancer has become a hotspot.MicroRNAs are small non-coding RNA molecules that can negatively regulate gene expression at the posttranscriptional level. A rapidly growing number of recent studies show that some aberrantly expressed miRNAs in ovarian cancer could target genes related to drug sensitivity，resulting in the altered sensitivity of cancer cells to anti-cancer drugs；the specific targeting of miRNAs could open new avenues for cancer treatment through overcoming drug resistance. These results suggest that miRNAs may be a potentially useful tool for prognostic stratification and individualized treatment.This review focused on the research progresses of miRNAs in ovarian cancer drug resistance and prognosis.

Key words: MicroRNAs, Gene expression regulation, Ovarian neoplasms, Carcinoma, Drug resistance, neoplasm